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- W3149728621 abstract "Background and Purpose—Perihematomal edema contributes to secondary brain injury in intracerebral hemorrhage (ICH). Increase of matrix metalloproteinases (MMPs) and growth factors is considerably involved in blood–brain barrier disruption and neuronal cell death in ICH models. We therefore hypothesized that increased levels of these molecular markers are associated with perihematomal edema and clinical outcome in ICH patients. Methods—Fifty-nine patients with spontaneous ICH admitted within 24 hours of symptom onset were prospectively investigated. Noncontrast CT was performed on admission for diagnosis of ICH and quantification of initial hematoma volume. MRI was performed on day 3 to evaluate perihematomal edema. Concentrations of MMP-3, MMP-9, as well as vascular endothelial growth factor and angiopoietin-1 on admission were determined by enzyme-linked immunosorbent assays. Clinical outcome was assessed by modified Rankin Scale at 90 days. Results—Increased MMP-3 levels were independently associated wi..." @default.
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- W3149728621 date "2013-01-01" @default.
- W3149728621 modified "2023-09-28" @default.
- W3149728621 title "Association of Molecular Markers With Perihematomal Edema and Clinical Outcome in Intracerebral Hemorrhage" @default.
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