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- W3149756827 abstract "A B S T R A C T In vivo plasminogen responses to various stimuli were studied. Plasminogen-'251 was prepared and used first for metabolic studies of plasminogen in control dogs. The average results were: the plasma plasminogen, 29.34±4.1 (SD) mg/kg; the interstitial plasminogen, 8.79±4.47 (SD) mg/kg; the half-life of plasma plasminogen-_251, 2.81±0.24 (SD) days; the fractional direct catabolic rate of plasminogen (jO), 0.295 day-'; and the catabolic (synthetic) rate of plasminogen, 8.61±1.35 (SD) mg/kg per day. Studies were then made of the plasminogen-251I responses in dogs to a single injection of urokinase (A) and typhoid vaccine (B), and to vascular injury (C), which was produced by the damage of venous endothelium by a phenol injection. Effects of heparin were also studied in dogs given the phenol injection (D). Disc electrophoretic analysis of plasma showed generation of plasmin-'251 in all except the control experiments. The duration of plasmin-125I generation was about 6 hr in A, 6 hr in B, and at least 5 days in C. Heparinization (D) shortened the duration of generation to about 6 hr. For further quantitative analysis of the tracer data, a model for coexistent plasminogen-1251 and plasmin-1251 was proposed and validated, from which some new analytical methods were derived. Using these methods, the average fractional rate of plasmin-1251 generation from plasminogen-1251 (j4) was 0.41 day-` in A, 0.30 day-1 in B, 0.324 day-1 in C, and 0.382 day'l in D. Further mathematical consideration showed that j3 was zero at least in C during plasmin generation. Plasminogen synthesis was unchanged in all experiments. The average fractional breakdown rate of plasmin-1251 (j5) in A, B, C, and D was 1.19, 1.13, 1.35, and 1.11 day-1, respectively, and were closely similar. These results indicate that under normal conditions a major portion of plasminogen is directly catabolized without the formation of plasmin," @default.
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- W3149756827 date "1972-01-01" @default.
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- W3149756827 title "Plasminogen-25I Responses in Dogs to a Single Injection of, Urokinase and Typhoid Vaccine and to Vascular Injury" @default.
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