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- W3149762695 abstract "Objective:To detect PD-1 protein expression in immune organs from bovine collagen Ⅱ(CII)-induced mouse rheumatoid arthritis(CIA)and synovial tissues of RA patients.Methods:The expression and distribution of PD-1 antigen was analyzed by immunohistochemistry.Moreover,flow cytometry(FACs)was further used to characterize PD-1 expression.Results:Immunohistochemical analysis revealed that PD-1 positive cells were found in thymus,spleen,lymph nodes and bone marrow,and FACs further demonstrated that PD-1 positive cells were CD3+ T cells,B220+ B cells,CD68+ macrophages or CD11c+ dendritic cells.However,the expression and distribution of PD-1 were not changed significantly between normal and CIA mice.Interestingly,seldom PD-1 positive cells were found both in synovial tissues of CIA mice and in RA patients.Conclusion:PD-1 signal might not be involved in regulating the pathogenesis of RA." @default.
- W3149762695 created "2021-04-13" @default.
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- W3149762695 date "2010-01-01" @default.
- W3149762695 modified "2023-09-25" @default.
- W3149762695 title "Expression and distribution of the co-inhibitory molecule PD-1 in tissues from rheumatoid arthritis" @default.
- W3149762695 hasPublicationYear "2010" @default.
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