Matches in SemOpenAlex for { <https://semopenalex.org/work/W3149763411> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W3149763411 abstract "AIM:To determine the structural determinants of the antiproliferative effect of heparin molecules on human mesangial cell.METHODS:Unfractionated heparin was separately desulfated,periodate-oxidized/borohydride-reduced,carboxyl-reduced and poly-sulfated by chemical modification.These heparin derivates were assayed for antiproliferative effects on cultured human mesangial cell compared with unfractionated heparin.RESULTS and CONCLUSION:2,3-O-desulfated heparin almost completely lost the antiproliferative activity at concentration between 0.01～1.5 mg·mL-1,6-O-desulfated,N-desulfated and carboxyl-reduced heparin significantly lost some activities compared with heparin,but periodate-oxidized/borohydride-reduced,poly-sulfated heparin and enoxaparin exhibited comparable growth-inhibition effects on human mesangial cell.The anticoagulation activity of heparin derivates markedly decreased by APTT.These data suggest that 2-O-or 3-O-sulfation is much more important than 6-O-and N-sulfation to antiproliferative activity.Sulfate and carboxyl are factors but not essential reasons.Antiproliferative effect is also independent on heparin polysaccharide chain,anticoagulation activity and molecular size exceeding 4.5 kDa." @default.
- W3149763411 created "2021-04-13" @default.
- W3149763411 creator A5032633355 @default.
- W3149763411 date "2008-01-01" @default.
- W3149763411 modified "2023-09-23" @default.
- W3149763411 title "Structural Determinants of the Antiproliferative Effect of Heparin Molecule on Human Mesangial Cell" @default.
- W3149763411 hasPublicationYear "2008" @default.
- W3149763411 type Work @default.
- W3149763411 sameAs 3149763411 @default.
- W3149763411 citedByCount "0" @default.
- W3149763411 crossrefType "journal-article" @default.
- W3149763411 hasAuthorship W3149763411A5032633355 @default.
- W3149763411 hasConcept C100817775 @default.
- W3149763411 hasConcept C116073593 @default.
- W3149763411 hasConcept C1491633281 @default.
- W3149763411 hasConcept C153074725 @default.
- W3149763411 hasConcept C155138218 @default.
- W3149763411 hasConcept C161790260 @default.
- W3149763411 hasConcept C185592680 @default.
- W3149763411 hasConcept C202751555 @default.
- W3149763411 hasConcept C2775909754 @default.
- W3149763411 hasConcept C2776789926 @default.
- W3149763411 hasConcept C2777557582 @default.
- W3149763411 hasConcept C2778931688 @default.
- W3149763411 hasConcept C2779131090 @default.
- W3149763411 hasConcept C55493867 @default.
- W3149763411 hasConcept C62112901 @default.
- W3149763411 hasConcept C86803240 @default.
- W3149763411 hasConcept C98274493 @default.
- W3149763411 hasConceptScore W3149763411C100817775 @default.
- W3149763411 hasConceptScore W3149763411C116073593 @default.
- W3149763411 hasConceptScore W3149763411C1491633281 @default.
- W3149763411 hasConceptScore W3149763411C153074725 @default.
- W3149763411 hasConceptScore W3149763411C155138218 @default.
- W3149763411 hasConceptScore W3149763411C161790260 @default.
- W3149763411 hasConceptScore W3149763411C185592680 @default.
- W3149763411 hasConceptScore W3149763411C202751555 @default.
- W3149763411 hasConceptScore W3149763411C2775909754 @default.
- W3149763411 hasConceptScore W3149763411C2776789926 @default.
- W3149763411 hasConceptScore W3149763411C2777557582 @default.
- W3149763411 hasConceptScore W3149763411C2778931688 @default.
- W3149763411 hasConceptScore W3149763411C2779131090 @default.
- W3149763411 hasConceptScore W3149763411C55493867 @default.
- W3149763411 hasConceptScore W3149763411C62112901 @default.
- W3149763411 hasConceptScore W3149763411C86803240 @default.
- W3149763411 hasConceptScore W3149763411C98274493 @default.
- W3149763411 hasLocation W31497634111 @default.
- W3149763411 hasOpenAccess W3149763411 @default.
- W3149763411 hasPrimaryLocation W31497634111 @default.
- W3149763411 hasRelatedWork W1041970429 @default.
- W3149763411 hasRelatedWork W1528225178 @default.
- W3149763411 hasRelatedWork W1588428776 @default.
- W3149763411 hasRelatedWork W1969640970 @default.
- W3149763411 hasRelatedWork W1980479109 @default.
- W3149763411 hasRelatedWork W1997183674 @default.
- W3149763411 hasRelatedWork W2005951667 @default.
- W3149763411 hasRelatedWork W2023938246 @default.
- W3149763411 hasRelatedWork W2041576050 @default.
- W3149763411 hasRelatedWork W2069233207 @default.
- W3149763411 hasRelatedWork W2069754293 @default.
- W3149763411 hasRelatedWork W2089133555 @default.
- W3149763411 hasRelatedWork W2092017537 @default.
- W3149763411 hasRelatedWork W2115518642 @default.
- W3149763411 hasRelatedWork W2140943483 @default.
- W3149763411 hasRelatedWork W2151857665 @default.
- W3149763411 hasRelatedWork W2152687923 @default.
- W3149763411 hasRelatedWork W2386938693 @default.
- W3149763411 hasRelatedWork W2793742498 @default.
- W3149763411 hasRelatedWork W2848895944 @default.
- W3149763411 isParatext "false" @default.
- W3149763411 isRetracted "false" @default.
- W3149763411 magId "3149763411" @default.
- W3149763411 workType "article" @default.