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- W3149772430 abstract "BRD7 is a novel bromodomain gene isolated by cDNA representational difference analysis （GenBank accession number:AF152604）. It is obviously down-regulated in nasopharyngeal carcinoma （NPC） cells and tissues. Over expression of BRD7 in NPC cells can inhibit cell proliferation and cell cycle progression. Previous studies determined the promoter region of BRD7 gene, and located this region in 450 bp （-404-- +46 bp）. In order to further explore the molecular mechanisms involved in the down-expression of BRD7 gene in NPC cells, we adopted bioinformatic approaches and found a consensus E2F6 binding site （-229-- -243 bp） in the promoter region of BRD7 gene. Results from EMSA indicated that transcription factor E2F6 could bind to BRD7 promoter. Over-expression of BRD7 gene inhibited BRD7 promoter activity detected by either luciferase assay or the expression of green fluorescent protein." @default.
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- W3149772430 date "2006-01-01" @default.
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- W3149772430 title "Overexpression of E2F6 gene inhibits promoter activity of BRD7 gene" @default.
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