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- W3149778718 abstract "Background: Colorectal cancer is the third most common cancer, and the second leading cause of cancer-related deaths. Up to 50% of patients with CRC will develop synchronic (10-20%) or metachronic (20-30%) CRLM. Currently, liver resection is the gold standard treatment for CRLM improving the prognosis significantly. Despite this, more than 50% of patients undergo recurrences after liver resections, most of them within the first 24 months after surgery. Objective: To describe rates and patterns of recurrence following liver resections for CRLM at The Queen Elizabeth Hospital, Adelaide as well as characterize clinical, pathological and treatment-related factors that could work as predictors of recurrence and survival. Methods: Retrospective analysis of a prospectively collected data base of 170 patients who underwent liver resections for CRLM at The Queen Elizabeth Hospital (Adelaide, Australia) between 2004 and 2017. Results: The incidence rate was 49,4% (84 of 170 patients), and the recurrences occurred mainly during the first year after the resective procedure (average 359 days). The intercurrence of perioperative chemotherapy was associated with a higher recurrence rate and a lower survival time in the univariate and multivariate analysis. The benefit of a margin resection greater or equal to 1mm was established. The other studied variables showed no statistical association. Conclusion: Despite the development of better diagnostic and therapeutic techniques for CRC and CRLM, its recurrence rate continues to be high and the survival time low. The role and impact of perioperative chemotherapy must continue to be studied in order to improve therapeutic outcomes for CRLM." @default.
- W3149778718 created "2021-04-13" @default.
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- W3149778718 date "2021-01-01" @default.
- W3149778718 modified "2023-09-26" @default.
- W3149778718 title "Effect of Quemotherapy and Tumor Clearance in Hepatic Resections for Colorectal Liver Metastases" @default.
- W3149778718 doi "https://doi.org/10.1016/j.hpb.2020.11.303" @default.
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