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- W3149781352 abstract "(CXCR4 ) CXC chemokine 受体 4 是被显示了调停的房间表面受体包括肺，胸，肾，和前列腺的许多稳固的肿瘤的转移肿瘤。在这研究，我们发现 et 变体基因 4 的 overexpression (PEA3 ) 能在人的 MDA-MB-231 和 MCF-7 乳癌房间提高 CXCR4 mRNA 水平和 CXCR4 倡导者活动。PEA3 支持了 CXCR4 表示和乳癌转移。染色质 immunoprecipitation 试金证明 PEA3 能与 PEA3 表示向量在房间 transfected 绑在 CXCR4 倡导者。PEA3 siRNA 在 MDA-MB-231 和 MCF-7 房间稀释了 CXCR4 倡导者活动和 PEA3 的绑定到 CXCR4 倡导者。这些结果显示 PEA3 能激活 CXCR4 倡导者抄写并且支持乳癌转移。" @default.
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- W3149781352 date "2011-01-01" @default.
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- W3149781352 title "PEA3 activates CXCR4 transcription in MDA-MB-231 and MCF7 breast cancer cells" @default.
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