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• W3149784639 endingPage "1079" @default.
• W3149784639 startingPage "1062" @default.
• W3149784639 abstract "Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) associates with a considerable high rate of mortality and represents currently the most important concern in global health. The risk of more severe clinical manifestation of COVID-19 is higher in males and steeply raised with age but also increased by the presence of chronic comorbidities. Among the latter, early reports suggested that arterial hypertension associates with higher susceptibility to SARS-CoV-2 infection, more severe course and increased COVID-19–related deaths. Furthermore, experimental studies suggested that key pathophysiological hypertension mechanisms, such as activation of the renin-angiotensin system (RAS), may play a role in COVID-19. In fact, ACE2 (angiotensin-converting-enzyme 2) is the pivotal receptor for SARS-CoV-2 to enter host cells and provides thus a link between COVID-19 and RAS. It was thus anticipated that drugs modulating the RAS including an upregulation of ACE2 may increase the risk for infection with SARS-CoV-2 and poorer outcomes in COVID-19. Since the use of RAS-blockers, ACE inhibitors or angiotensin receptor blockers, represents the backbone of recommended antihypertensive therapy and intense debate about their use in the COVID-19 pandemic has developed. Currently, a direct role of hypertension, independent of age and other comorbidities, as a risk factor for the SARS-COV-2 infection and COVID-19 outcome, particularly death, has not been established. Similarly, both current experimental and clinical studies do not support an unfavorable effect of RAS-blockers or other classes of first line blood pressure lowering drugs in COVID-19. Here, we review available data on the role of hypertension and its management on COVID-19. Conversely, some aspects as to how the COVID-19 affects hypertension management and impacts on future developments are also briefly discussed. COVID-19 has and continues to proof the critical importance of hypertension research to address questions that are important for global health." @default.
• W3149784639 created "2021-04-13" @default.
• W3149784639 creator A5020814480 @default.
• W3149784639 creator A5054282642 @default.
• W3149784639 creator A5091895035 @default.
• W3149784639 date "2021-04-02" @default.
• W3149784639 modified "2023-10-07" @default.
• W3149784639 title "Hypertension, a Moving Target in COVID-19" @default.
• W3149784639 cites W1595363731 @default.
• W3149784639 cites W1925591757 @default.
• W3149784639 cites W1966238900 @default.
• W3149784639 cites W1974043792 @default.
• W3149784639 cites W2002241222 @default.
• W3149784639 cites W2003085134 @default.
• W3149784639 cites W2011595187 @default.
• W3149784639 cites W2017821597 @default.
• W3149784639 cites W2025672718 @default.
• W3149784639 cites W2028439883 @default.
• W3149784639 cites W2034426742 @default.
• W3149784639 cites W2041717330 @default.
• W3149784639 cites W2045052478 @default.
• W3149784639 cites W2049579241 @default.
• W3149784639 cites W2081575691 @default.
• W3149784639 cites W2085499708 @default.
• W3149784639 cites W2127877077 @default.
• W3149784639 cites W2129812418 @default.
• W3149784639 cites W2143146725 @default.
• W3149784639 cites W2153626991 @default.
• W3149784639 cites W2159415544 @default.
• W3149784639 cites W2161399617 @default.
• W3149784639 cites W2168671157 @default.
• W3149784639 cites W2396221546 @default.
• W3149784639 cites W2427094903 @default.
• W3149784639 cites W2572331255 @default.
• W3149784639 cites W2588717414 @default.
• W3149784639 cites W2616436626 @default.
• W3149784639 cites W2768267412 @default.
• W3149784639 cites W2769170966 @default.
• W3149784639 cites W2772240339 @default.
• W3149784639 cites W2780715796 @default.
• W3149784639 cites W2793955071 @default.
• W3149784639 cites W2803875087 @default.
• W3149784639 cites W2888394889 @default.
• W3149784639 cites W2894724600 @default.
• W3149784639 cites W2898490904 @default.
• W3149784639 cites W2907284663 @default.
• W3149784639 cites W2913386382 @default.
• W3149784639 cites W2968716215 @default.
• W3149784639 cites W2969292601 @default.
• W3149784639 cites W2977713107 @default.
• W3149784639 cites W2994353806 @default.
• W3149784639 cites W2994740578 @default.
• W3149784639 cites W2999981125 @default.
• W3149784639 cites W3005561939 @default.
• W3149784639 cites W3008065272 @default.
• W3149784639 cites W3008827533 @default.
• W3149784639 cites W3008928028 @default.
• W3149784639 cites W3009063690 @default.
• W3149784639 cites W3009335299 @default.
• W3149784639 cites W3009383606 @default.
• W3149784639 cites W3009885589 @default.
• W3149784639 cites W3009912996 @default.
• W3149784639 cites W3011134208 @default.
• W3149784639 cites W3011439019 @default.
• W3149784639 cites W3012290708 @default.
• W3149784639 cites W3012421327 @default.
• W3149784639 cites W3012625735 @default.
• W3149784639 cites W3012725239 @default.
• W3149784639 cites W3013302817 @default.
• W3149784639 cites W3013500709 @default.
• W3149784639 cites W3014067025 @default.
• W3149784639 cites W3014099229 @default.
• W3149784639 cites W3014105681 @default.
• W3149784639 cites W3014427579 @default.
• W3149784639 cites W3014571869 @default.
• W3149784639 cites W3014667074 @default.
• W3149784639 cites W3015134137 @default.
• W3149784639 cites W3016182787 @default.
• W3149784639 cites W3016259848 @default.
• W3149784639 cites W3016535995 @default.
• W3149784639 cites W3016572296 @default.
• W3149784639 cites W3017125154 @default.
• W3149784639 cites W3018087367 @default.
• W3149784639 cites W3018302731 @default.
• W3149784639 cites W3021406499 @default.
• W3149784639 cites W3021992825 @default.
• W3149784639 cites W3022149127 @default.
• W3149784639 cites W3022572398 @default.
• W3149784639 cites W3022580747 @default.
• W3149784639 cites W3023640683 @default.
• W3149784639 cites W3023751598 @default.
• W3149784639 cites W3024126428 @default.
• W3149784639 cites W3024193040 @default.
• W3149784639 cites W3025099648 @default.
• W3149784639 cites W3025200871 @default.
• W3149784639 cites W3026764413 @default.
• W3149784639 cites W3027918021 @default.
• W3149784639 cites W3029347845 @default.

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