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- W3149785518 abstract "The cellular mechanisms of Wenckebach periodicity were investigated in single, enzymatically dissociated guinea pig ventricular myocytes, as well as in computer reconstructions of transmembrane potential of the ventricular cell. When depolarizing current pulses of the appropriate magnitude were delivered repetitively to a well-polarized myocyte, rate-dependent activation failure was observed. Such behavior accurately mimicked the Wenckebach phenomenon in cardiac activation and was the consequence of variations in cell excitability during the diastolic phase of the cardiac cycle. The recovery of cell excitability during diastole was studied through the application of single test pulses of fixed amplitude and duration at variable delays with respect to a basic train of normal action potentials. The results show that recovery of excitability is a slow process that can greatly outlast action potential duration (i.e., postrepolarization refractoriness). Two distinct types of subthreshold responses were recorde..." @default.
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- W3149785518 date "1989-01-01" @default.
- W3149785518 modified "2023-09-26" @default.
- W3149785518 title "Slow recovery of excitability and the Wenckebach phenomenon in the single guinea pig ventricular myocyte." @default.
- W3149785518 hasPublicationYear "1989" @default.
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