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- W3149786546 abstract "主要胆汁的肝硬化(PBC ) 是主要影响女人的器官特定的自体免疫的疾病并且被 smallintrahepatic 胆汁管的长期的、进步破坏与门发炎描绘，导致当治疗不在时的肝失败并且最终纤维变性。很少对 PBC 的病原学被知道。PBC 是描绘的 byanti-mitochondrial 抗体和 intra 肝的胆汁管的破坏。serologic 特点 ofPBC 是到线粒体的自身抗体的存在，特别到 thepyruvate 脱氢酶建筑群(PDC ) 的 E2 部件。PBC 的致病上的当前的理论赞成疾病由一个环境或传染的代理人由于不恰当的有免疫力的反应追随者刺激开发的假设。一些报告建议 xenobiotics 和病毒的感染可以导致 PBC。病原的机制被相信被缺点 inimmunologic 忍耐引起，导致特定的 T 和 Blymphocyte 克隆的自我抗原和除了无数 ofcytokines 和另外的煽动性的调停人的传播自身抗体的生产的激活和扩大。这导致 ductulopenia 和坚持的 cholestasis，由开发结束阶段肝房间的失败。关于 intrahepatic cholestasis 的开发和它的修正的可能的方法的机制在这评论被给我们的自己和文学数据。" @default.
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- W3149786546 date "2006-01-01" @default.
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- W3149786546 title "Concept on the pathogenesis and treatment of primary biliary cirrhosis" @default.
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