Matches in SemOpenAlex for { <https://semopenalex.org/work/W3149792854> ?p ?o ?g. }
- W3149792854 endingPage "372" @default.
- W3149792854 startingPage "372" @default.
- W3149792854 abstract "Despite extensive research, there is no convincing evidence of a reliable diagnostic biomarker for schizophrenia beyond clinical observation. Disorders of glutamatergic neurotransmission associated with N-methyl-D-aspartate (NMDA) receptor insufficiency, neuroinflammation, and redox dysregulation are the principal common mechanism linking changes in the periphery with the brain, ultimately contributing to the emergence of negative symptoms of schizophrenia that underlie differential diagnosis. The aim of the study was to evaluate the influence of these systems via peripheral and cerebral biochemical indices in relation to the patient’s clinical condition. Using neuroimaging diagnostics, we were able to define endophenotypes of schizophrenia based on objective laboratory data that form the basis of a personalized approach to diagnosis and treatment. The two distinguished endophenotypes differed in terms of the quality of life, specific schizophrenia symptoms, and glutamatergic neurotransmission metabolites in the anterior cingulate gyrus. Our results, as well as further studies of the excitatory or inhibitory balance of microcircuits, relating the redox systems on the periphery with the distant regions of the brain might allow for predicting potential biomarkers of neuropsychiatric diseases, including schizophrenia. To the best of our knowledge, our study is the first to identify an objective molecular biomarker of schizophrenia outcome." @default.
- W3149792854 created "2021-04-13" @default.
- W3149792854 creator A5010002457 @default.
- W3149792854 creator A5029952748 @default.
- W3149792854 creator A5041437162 @default.
- W3149792854 creator A5049374648 @default.
- W3149792854 creator A5054156168 @default.
- W3149792854 creator A5072618671 @default.
- W3149792854 creator A5081586229 @default.
- W3149792854 creator A5087984894 @default.
- W3149792854 date "2021-04-01" @default.
- W3149792854 modified "2023-09-24" @default.
- W3149792854 title "Determinants of Schizophrenia Endophenotypes Based on Neuroimaging and Biochemical Parameters" @default.
- W3149792854 cites W1518890501 @default.
- W3149792854 cites W1625479408 @default.
- W3149792854 cites W1713912842 @default.
- W3149792854 cites W1914381346 @default.
- W3149792854 cites W1963383010 @default.
- W3149792854 cites W1976057168 @default.
- W3149792854 cites W1989598267 @default.
- W3149792854 cites W2005068710 @default.
- W3149792854 cites W2022355264 @default.
- W3149792854 cites W2023328851 @default.
- W3149792854 cites W2038310571 @default.
- W3149792854 cites W2051607590 @default.
- W3149792854 cites W2057878573 @default.
- W3149792854 cites W2063765492 @default.
- W3149792854 cites W2067073611 @default.
- W3149792854 cites W2078881206 @default.
- W3149792854 cites W2082707665 @default.
- W3149792854 cites W2087119802 @default.
- W3149792854 cites W2094421200 @default.
- W3149792854 cites W2112492148 @default.
- W3149792854 cites W2119258483 @default.
- W3149792854 cites W2140606211 @default.
- W3149792854 cites W2143126574 @default.
- W3149792854 cites W2146738944 @default.
- W3149792854 cites W2165292984 @default.
- W3149792854 cites W2168587728 @default.
- W3149792854 cites W2202688183 @default.
- W3149792854 cites W2218229014 @default.
- W3149792854 cites W2416599592 @default.
- W3149792854 cites W2430831277 @default.
- W3149792854 cites W2461990518 @default.
- W3149792854 cites W2501753829 @default.
- W3149792854 cites W2517266214 @default.
- W3149792854 cites W2551102722 @default.
- W3149792854 cites W2562593128 @default.
- W3149792854 cites W2567157970 @default.
- W3149792854 cites W2591911682 @default.
- W3149792854 cites W2596753163 @default.
- W3149792854 cites W2598169304 @default.
- W3149792854 cites W2740094929 @default.
- W3149792854 cites W2761730641 @default.
- W3149792854 cites W2765573221 @default.
- W3149792854 cites W2776651958 @default.
- W3149792854 cites W2789854309 @default.
- W3149792854 cites W2797047348 @default.
- W3149792854 cites W2797279841 @default.
- W3149792854 cites W2801180445 @default.
- W3149792854 cites W2810906666 @default.
- W3149792854 cites W2911023731 @default.
- W3149792854 cites W2922242403 @default.
- W3149792854 cites W2941069847 @default.
- W3149792854 cites W2946560124 @default.
- W3149792854 cites W2949412502 @default.
- W3149792854 cites W2990116051 @default.
- W3149792854 cites W2999019869 @default.
- W3149792854 cites W3010035230 @default.
- W3149792854 cites W3011587007 @default.
- W3149792854 cites W3034993845 @default.
- W3149792854 cites W3036823882 @default.
- W3149792854 cites W3047344576 @default.
- W3149792854 cites W3047563511 @default.
- W3149792854 cites W3080088206 @default.
- W3149792854 cites W3082204994 @default.
- W3149792854 cites W3086533835 @default.
- W3149792854 cites W3092911361 @default.
- W3149792854 cites W3118620774 @default.
- W3149792854 cites W2773726752 @default.
- W3149792854 doi "https://doi.org/10.3390/biomedicines9040372" @default.
- W3149792854 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8066217" @default.
- W3149792854 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33916324" @default.
- W3149792854 hasPublicationYear "2021" @default.
- W3149792854 type Work @default.
- W3149792854 sameAs 3149792854 @default.
- W3149792854 citedByCount "5" @default.
- W3149792854 countsByYear W31497928542022 @default.
- W3149792854 countsByYear W31497928542023 @default.
- W3149792854 crossrefType "journal-article" @default.
- W3149792854 hasAuthorship W3149792854A5010002457 @default.
- W3149792854 hasAuthorship W3149792854A5029952748 @default.
- W3149792854 hasAuthorship W3149792854A5041437162 @default.
- W3149792854 hasAuthorship W3149792854A5049374648 @default.
- W3149792854 hasAuthorship W3149792854A5054156168 @default.
- W3149792854 hasAuthorship W3149792854A5072618671 @default.
- W3149792854 hasAuthorship W3149792854A5081586229 @default.
- W3149792854 hasAuthorship W3149792854A5087984894 @default.