Matches in SemOpenAlex for { <https://semopenalex.org/work/W3149798236> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W3149798236 abstract "Abstract Prevailing COVID-19 vaccines are based on the spike protein of earlier SARS-CoV-2 strain that emerged in Wuhan, China. The continuously evolving nature of SARS-CoV-2 resulting emergence of new variants raises the risk of immune absconds. During the last few months, several RBD (receptor-binding domain) variants have been reported to affect the vaccine efficacy considerably. Soon after reporting of a new double mutant variant (L452R & E484Q) in India, the country facing a deadlier second wave of infections which prompts researchers to suspects this variant to be accountable. To address the relevant concerns about this new variant affecting vaccine efficacy, we performed molecular simulation dynamics based structural analysis of spike protein of double mutant (L452R & E484Q) along with K417G variants and earlier reported RBD variants and found structural changes in RBD region after comparing with the wild type. Comparison of the binding affinity of the double mutant and earlier reported RBD variant for ACE2 (angiotensin 2 altered enzymes) receptor and CR3022 antibody with the wild-type strain revealed the lowest binding affinity of the double mutant for CR3022 among all other variants. These findings suggest that the newly emerged double mutant could significantly reduce the impact of the current vaccine which threatens the protective efficacy of current vaccine therapy." @default.
- W3149798236 created "2021-04-13" @default.
- W3149798236 creator A5017650842 @default.
- W3149798236 creator A5026738122 @default.
- W3149798236 creator A5058252457 @default.
- W3149798236 creator A5061516944 @default.
- W3149798236 date "2021-04-04" @default.
- W3149798236 modified "2023-09-25" @default.
- W3149798236 title "Bioinformatics analysis of SARS-CoV-2 RBD mutant variants and insights into antibody and ACE2 receptor binding" @default.
- W3149798236 cites W1517622624 @default.
- W3149798236 cites W1966078827 @default.
- W3149798236 cites W1975490802 @default.
- W3149798236 cites W2025977980 @default.
- W3149798236 cites W2080708468 @default.
- W3149798236 cites W2081912151 @default.
- W3149798236 cites W2982027655 @default.
- W3149798236 cites W3004348779 @default.
- W3149798236 cites W3010441732 @default.
- W3149798236 cites W3010780802 @default.
- W3149798236 cites W3035950190 @default.
- W3149798236 cites W3039901154 @default.
- W3149798236 cites W3046445222 @default.
- W3149798236 cites W3093148997 @default.
- W3149798236 cites W3117861006 @default.
- W3149798236 cites W3123108673 @default.
- W3149798236 cites W3132479927 @default.
- W3149798236 cites W3133789246 @default.
- W3149798236 cites W3154868788 @default.
- W3149798236 doi "https://doi.org/10.1101/2021.04.03.438113" @default.
- W3149798236 hasPublicationYear "2021" @default.
- W3149798236 type Work @default.
- W3149798236 sameAs 3149798236 @default.
- W3149798236 citedByCount "4" @default.
- W3149798236 countsByYear W31497982362020 @default.
- W3149798236 countsByYear W31497982362021 @default.
- W3149798236 countsByYear W31497982362022 @default.
- W3149798236 countsByYear W31497982362023 @default.
- W3149798236 crossrefType "posted-content" @default.
- W3149798236 hasAuthorship W3149798236A5017650842 @default.
- W3149798236 hasAuthorship W3149798236A5026738122 @default.
- W3149798236 hasAuthorship W3149798236A5058252457 @default.
- W3149798236 hasAuthorship W3149798236A5061516944 @default.
- W3149798236 hasBestOaLocation W31497982361 @default.
- W3149798236 hasConcept C104317684 @default.
- W3149798236 hasConcept C126322002 @default.
- W3149798236 hasConcept C143065580 @default.
- W3149798236 hasConcept C159047783 @default.
- W3149798236 hasConcept C159654299 @default.
- W3149798236 hasConcept C170493617 @default.
- W3149798236 hasConcept C2779134260 @default.
- W3149798236 hasConcept C2780441014 @default.
- W3149798236 hasConcept C2909509916 @default.
- W3149798236 hasConcept C3007834351 @default.
- W3149798236 hasConcept C3008058167 @default.
- W3149798236 hasConcept C501734568 @default.
- W3149798236 hasConcept C524204448 @default.
- W3149798236 hasConcept C54355233 @default.
- W3149798236 hasConcept C71924100 @default.
- W3149798236 hasConcept C86803240 @default.
- W3149798236 hasConceptScore W3149798236C104317684 @default.
- W3149798236 hasConceptScore W3149798236C126322002 @default.
- W3149798236 hasConceptScore W3149798236C143065580 @default.
- W3149798236 hasConceptScore W3149798236C159047783 @default.
- W3149798236 hasConceptScore W3149798236C159654299 @default.
- W3149798236 hasConceptScore W3149798236C170493617 @default.
- W3149798236 hasConceptScore W3149798236C2779134260 @default.
- W3149798236 hasConceptScore W3149798236C2780441014 @default.
- W3149798236 hasConceptScore W3149798236C2909509916 @default.
- W3149798236 hasConceptScore W3149798236C3007834351 @default.
- W3149798236 hasConceptScore W3149798236C3008058167 @default.
- W3149798236 hasConceptScore W3149798236C501734568 @default.
- W3149798236 hasConceptScore W3149798236C524204448 @default.
- W3149798236 hasConceptScore W3149798236C54355233 @default.
- W3149798236 hasConceptScore W3149798236C71924100 @default.
- W3149798236 hasConceptScore W3149798236C86803240 @default.
- W3149798236 hasLocation W31497982361 @default.
- W3149798236 hasOpenAccess W3149798236 @default.
- W3149798236 hasPrimaryLocation W31497982361 @default.
- W3149798236 hasRelatedWork W101124211 @default.
- W3149798236 hasRelatedWork W1897859244 @default.
- W3149798236 hasRelatedWork W2009647017 @default.
- W3149798236 hasRelatedWork W2024850895 @default.
- W3149798236 hasRelatedWork W2117110650 @default.
- W3149798236 hasRelatedWork W2147466517 @default.
- W3149798236 hasRelatedWork W3036305013 @default.
- W3149798236 hasRelatedWork W3127693599 @default.
- W3149798236 hasRelatedWork W4210401150 @default.
- W3149798236 hasRelatedWork W4385264226 @default.
- W3149798236 isParatext "false" @default.
- W3149798236 isRetracted "false" @default.
- W3149798236 magId "3149798236" @default.
- W3149798236 workType "article" @default.