FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3149798908> ?p ?o ?g. }

• W3149798908 endingPage "514" @default.
• W3149798908 startingPage "504" @default.
• W3149798908 abstract "A systematic review was conducted on published data of subacute combined degeneration (SCD) from B12 deficiency to investigate potential prognostic indicators of final ambulatory function in affected patients. TYPE: Systematic review.Records published from 1999 through 2018 were searched on the electronic databases MEDLINE, PUBMED, and SCOPUS. The publication language was restricted to English and French.Records that described cases of SCD from B12 deficiency in patients ≥16 years of age at onset were included. From a final total of 66 cases of SCD identified, ambulation scores were assigned based on the clinical descriptions reported. Patient characteristics, clinical manifestations, and ambulatory function were reported descriptively. Subanalyses on potential prognostic indicators were performed.Greater ambulatory function at diagnosis was associated with recovery of normal ambulatory function at follow-up (P < .001). Nearly 90% of patients walking unsupported at diagnosis made a complete recovery regardless of etiology. For patients initially walking with support, 22% of cases from impaired B12 digestion/absorption made a complete recovery compared with ≥50% of cases from other etiologies. For patients initially requiring a wheelchair, 33% of cases from impaired digestion/absorption were able to walk with support compared with ≥50% of cases from other etiologies. The total B12 administered over the course of treatment was correlated with improved ambulation (P = .024) for all patients, with a higher B12 replacement regimen associated with better outcomes in patients who were unable to walk unsupported at diagnosis (number needed to treat = 4).Initial ambulatory function may be a useful clinical marker of the severity of spinal cord dysfunction and final functional outcome. Etiological risk factors influenced both clinical manifestations and final walking ability in SCD, suggesting a distinct pathophysiological mechanism among the causes. In addition, a more intensive B12 replacement regimen may improve ultimate ambulatory function in advanced cases of SCD." @default.
• W3149798908 created "2021-04-13" @default.
• W3149798908 creator A5018902552 @default.
• W3149798908 creator A5021912458 @default.
• W3149798908 creator A5039925291 @default.
• W3149798908 creator A5056932295 @default.
• W3149798908 creator A5091045955 @default.
• W3149798908 date "2021-05-19" @default.
• W3149798908 modified "2023-10-16" @default.
• W3149798908 title "Prognostic indicators of subacute combined degeneration from B12 deficiency: A systematic review" @default.
• W3149798908 cites W10416642 @default.
• W3149798908 cites W1518833435 @default.
• W3149798908 cites W1756664299 @default.
• W3149798908 cites W1964658450 @default.
• W3149798908 cites W1970053993 @default.
• W3149798908 cites W1970166675 @default.
• W3149798908 cites W1978853703 @default.
• W3149798908 cites W198052940 @default.
• W3149798908 cites W1981813782 @default.
• W3149798908 cites W1987185275 @default.
• W3149798908 cites W1992552778 @default.
• W3149798908 cites W1993358518 @default.
• W3149798908 cites W1997140472 @default.
• W3149798908 cites W1999991754 @default.
• W3149798908 cites W2002723442 @default.
• W3149798908 cites W2002930951 @default.
• W3149798908 cites W2005539210 @default.
• W3149798908 cites W2005613328 @default.
• W3149798908 cites W2012655482 @default.
• W3149798908 cites W2015508653 @default.
• W3149798908 cites W2015672941 @default.
• W3149798908 cites W2020862519 @default.
• W3149798908 cites W2021327183 @default.
• W3149798908 cites W2026533696 @default.
• W3149798908 cites W2027113002 @default.
• W3149798908 cites W2030569765 @default.
• W3149798908 cites W2030726285 @default.
• W3149798908 cites W2035327733 @default.
• W3149798908 cites W2041708269 @default.
• W3149798908 cites W2044710719 @default.
• W3149798908 cites W2045387437 @default.
• W3149798908 cites W2057089482 @default.
• W3149798908 cites W2058152674 @default.
• W3149798908 cites W2063205882 @default.
• W3149798908 cites W2065718446 @default.
• W3149798908 cites W2066523188 @default.
• W3149798908 cites W2072015477 @default.
• W3149798908 cites W2075733942 @default.
• W3149798908 cites W2075762487 @default.
• W3149798908 cites W2076419966 @default.
• W3149798908 cites W2077469288 @default.
• W3149798908 cites W2078196989 @default.
• W3149798908 cites W2081055198 @default.
• W3149798908 cites W2083560353 @default.
• W3149798908 cites W2084269256 @default.
• W3149798908 cites W2107040137 @default.
• W3149798908 cites W2129948893 @default.
• W3149798908 cites W2131481256 @default.
• W3149798908 cites W2135092686 @default.
• W3149798908 cites W2144178379 @default.
• W3149798908 cites W2156930745 @default.
• W3149798908 cites W2158431456 @default.
• W3149798908 cites W2165582369 @default.
• W3149798908 cites W2169913496 @default.
• W3149798908 cites W2268967520 @default.
• W3149798908 cites W2283830518 @default.
• W3149798908 cites W2323501631 @default.
• W3149798908 cites W2326469489 @default.
• W3149798908 cites W2326941087 @default.
• W3149798908 cites W2328547952 @default.
• W3149798908 cites W2469982683 @default.
• W3149798908 cites W2492957485 @default.
• W3149798908 cites W2524174825 @default.
• W3149798908 cites W2592898407 @default.
• W3149798908 cites W2600797902 @default.
• W3149798908 cites W2619760666 @default.
• W3149798908 cites W2744400000 @default.
• W3149798908 cites W2779171838 @default.
• W3149798908 cites W2785002587 @default.
• W3149798908 cites W2786592139 @default.
• W3149798908 cites W2801325520 @default.
• W3149798908 cites W2869371872 @default.
• W3149798908 cites W2887919222 @default.
• W3149798908 cites W2891003733 @default.
• W3149798908 cites W3191926023 @default.
• W3149798908 cites W3215299411 @default.
• W3149798908 cites W4240348433 @default.
• W3149798908 cites W52309428 @default.
• W3149798908 cites W52603844 @default.
• W3149798908 doi "https://doi.org/10.1002/pmrj.12600" @default.
• W3149798908 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33780172" @default.
• W3149798908 hasPublicationYear "2021" @default.
• W3149798908 type Work @default.
• W3149798908 sameAs 3149798908 @default.
• W3149798908 citedByCount "0" @default.
• W3149798908 crossrefType "journal-article" @default.
• W3149798908 hasAuthorship W3149798908A5018902552 @default.
• W3149798908 hasAuthorship W3149798908A5021912458 @default.

• next