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- W3149803003 abstract "Survivin is a member of the inhibitor of apoptosis protein family that is overexpressed in various tumors and is important in restricting apoptosis. Under- standing the molecular events of apoptosis may provide information for developing novel therapeutic agents tar- geting non-small cell lung cancer (NSCLCs). This study used three human NSCLC cell lines, NCI-H1299, SK- MES-1, and NCI-H460. Changes in apoptosis, the mRNA and protein expression of survivin under normoxia and hypoxia, with or without rapamycin treatment were ana- lyzed. In addition, siRNA and ChIP assay were further applied to demonstrate the role of hypoxia-inducible factor 1 (HIF-1)a in regulating survivin expression regulation under hypoxia during rapamycin induced NSCLC cell apoptosis. Treatment with rapamycin resulted in signifi- cantly increased NSCLC cells apoptosis under hypoxia. We demonstrated for the first time that rapamycin inhibited hypoxia-induced survivin expression in NSCLC cell lines. We further demonstrated that HIF-1a participated in hypoxia-induced survivin expression, and that rapamycin inhibited hypoxia-induced HIF-1a expression by enhancing its degradation. The results above collectively showed that rapamycin inhibits HIF-1a-induced survivin expression under hypoxia to induce NSCLC apoptosis." @default.
- W3149803003 created "2021-04-13" @default.
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- W3149803003 date "2012-01-01" @default.
- W3149803003 modified "2023-09-27" @default.
- W3149803003 title "Rapamycin decreases survivin expression to induce NSCLC cell apoptosis under hypoxia through inhibiting HIF-1a induction" @default.
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