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- W3149806972 abstract "Drug metabolism and pharmacokinetics (DMPK) are fundamental in drug discovery. New chemical entities (NCEs) are typically evaluated with various in vitro and in vivo assays, which are time-consuming and labor intensive. These experiments are essential in identifying potential new drugs. Recently, mass spectrometry (MS) has played a key role in examining the drug-like properties of NCEs. Quantitative and qualitative mass spectrometry approaches are routinely utilized to obtain high-quality data in an efficient, timely, and cost-effective manner. Especially, liquid chromatography (LC) coupled with MS technology has been refined for metabolite identification (Met ID), which is critical for lead optimization. These qualitative and quantitative MS approaches and their specific utility in DMPK characterization will be described in this chapter." @default.
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- W3149806972 date "2021-01-01" @default.
- W3149806972 modified "2023-10-16" @default.
- W3149806972 title "The Application of Mass Spectrometry in Drug Metabolism and Pharmacokinetics" @default.
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- W3149806972 doi "https://doi.org/10.1007/978-981-33-6064-8_20" @default.
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