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- W3149807728 abstract "Abstract Alternative splicing (AS) regulates gene expression patterns at the post-transcriptional level and generates a striking expansion of coding capacities of genomes and cellular protein diversity. RNA splicing could undergo modulation and close interaction with genetic and epigenetic machinery. Notably, during the adipogenesis processes of white, brown and beige adipocytes, AS tightly interplays with the differentiation gene program networks. Here, we integrate the available findings on specific splicing events and distinct functions of different splicing regulators as examples to highlight the directive biological contribution of AS mechanism in adipogenesis and adipocyte biology. Furthermore, accumulating evidence has suggested that mutations and/or altered expression in splicing regulators and aberrant splicing alterations in the obesity-associated genes are often linked to humans’ diet-induced obesity and metabolic dysregulation phenotypes. Therefore, significant attempts have been finally made to overview novel detailed discussion on the prospects of splicing machinery with obesity and metabolic disorders to supply featured potential management mechanisms in clinical applicability for obesity treatment strategies." @default.
- W3149807728 created "2021-04-13" @default.
- W3149807728 creator A5009127013 @default.
- W3149807728 creator A5013604432 @default.
- W3149807728 creator A5025610773 @default.
- W3149807728 creator A5027228718 @default.
- W3149807728 creator A5056945892 @default.
- W3149807728 creator A5057223333 @default.
- W3149807728 creator A5060442973 @default.
- W3149807728 creator A5062932350 @default.
- W3149807728 creator A5063562624 @default.
- W3149807728 creator A5068192487 @default.
- W3149807728 date "2021-04-01" @default.
- W3149807728 modified "2023-10-17" @default.
- W3149807728 title "Regulatory roles and mechanisms of alternative RNA splicing in adipogenesis and human metabolic health" @default.
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