Matches in SemOpenAlex for { <https://semopenalex.org/work/W3149829340> ?p ?o ?g. }
Showing items 1 to 71 of
71
with 100 items per page.
- W3149829340 abstract "Objective To determine the effects of probucol on serum parameters and liver histopathology in rats with nonalcoholic steatohepatitis(NASH) and explore the mechanisms.Methods Forty male Sprague- Dawley rats were randomly assigned into 4 equal groups,namely the normal control group(NC group) with a standard feeding,high-fat diet group(HD group) fed with a high- fat diet,probucol(500 mg/kg daily) control group(NP group) fed with standard diet,and probucol group fed with a high-fat diet(HP group).After 15 weeks of feeding,the rats were euthanized for histopathological inspection of the liver with HE staining and detection of farnesoid X receptor(FXR),SHP and SREBP- 1C expressions using semiquantitative RT- PCR and Western blotting.Results After the 15- week feeding,the rats in HP group had significantly lower levels of serum ALT,AST,cholesterol,bile acid,and free fatty acid than those in HD group(P0.01 or 0.05).Compared with the normal control group,high-fat diet feeding resulted in significantly decreased mRNA and protein levels of FXR and SHP(P 0.05) and significantly increased SREBP-1C level(P0.05).These high-fat diet-induced gene expression changes were reversed by probucol intervention(P0.05).Conclusion Probucol treatment has beneficial effects on serum parameters,hepatic steatosis,and lobular inflammation in high-fat diet-induced NASH possibly by up-regulating FXR expression." @default.
- W3149829340 created "2021-04-13" @default.
- W3149829340 creator A5004663653 @default.
- W3149829340 date "2014-01-01" @default.
- W3149829340 modified "2023-09-23" @default.
- W3149829340 title "Effect of probucol in improving hepatic steatosis in rats with non- alcoholic steatohepatitis and the mechanism" @default.
- W3149829340 hasPublicationYear "2014" @default.
- W3149829340 type Work @default.
- W3149829340 sameAs 3149829340 @default.
- W3149829340 citedByCount "0" @default.
- W3149829340 crossrefType "journal-article" @default.
- W3149829340 hasAuthorship W3149829340A5004663653 @default.
- W3149829340 hasConcept C104317684 @default.
- W3149829340 hasConcept C126322002 @default.
- W3149829340 hasConcept C134018914 @default.
- W3149829340 hasConcept C185592680 @default.
- W3149829340 hasConcept C203862802 @default.
- W3149829340 hasConcept C2776167589 @default.
- W3149829340 hasConcept C2776175330 @default.
- W3149829340 hasConcept C2778163477 @default.
- W3149829340 hasConcept C2778772119 @default.
- W3149829340 hasConcept C2779134260 @default.
- W3149829340 hasConcept C2779478299 @default.
- W3149829340 hasConcept C55493867 @default.
- W3149829340 hasConcept C63932345 @default.
- W3149829340 hasConcept C71924100 @default.
- W3149829340 hasConcept C86339819 @default.
- W3149829340 hasConcept C86803240 @default.
- W3149829340 hasConceptScore W3149829340C104317684 @default.
- W3149829340 hasConceptScore W3149829340C126322002 @default.
- W3149829340 hasConceptScore W3149829340C134018914 @default.
- W3149829340 hasConceptScore W3149829340C185592680 @default.
- W3149829340 hasConceptScore W3149829340C203862802 @default.
- W3149829340 hasConceptScore W3149829340C2776167589 @default.
- W3149829340 hasConceptScore W3149829340C2776175330 @default.
- W3149829340 hasConceptScore W3149829340C2778163477 @default.
- W3149829340 hasConceptScore W3149829340C2778772119 @default.
- W3149829340 hasConceptScore W3149829340C2779134260 @default.
- W3149829340 hasConceptScore W3149829340C2779478299 @default.
- W3149829340 hasConceptScore W3149829340C55493867 @default.
- W3149829340 hasConceptScore W3149829340C63932345 @default.
- W3149829340 hasConceptScore W3149829340C71924100 @default.
- W3149829340 hasConceptScore W3149829340C86339819 @default.
- W3149829340 hasConceptScore W3149829340C86803240 @default.
- W3149829340 hasLocation W31498293401 @default.
- W3149829340 hasOpenAccess W3149829340 @default.
- W3149829340 hasPrimaryLocation W31498293401 @default.
- W3149829340 hasRelatedWork W1985309058 @default.
- W3149829340 hasRelatedWork W2016776263 @default.
- W3149829340 hasRelatedWork W2072855641 @default.
- W3149829340 hasRelatedWork W2116239522 @default.
- W3149829340 hasRelatedWork W2286143783 @default.
- W3149829340 hasRelatedWork W2349805603 @default.
- W3149829340 hasRelatedWork W2352132550 @default.
- W3149829340 hasRelatedWork W2354486364 @default.
- W3149829340 hasRelatedWork W2358094168 @default.
- W3149829340 hasRelatedWork W2363018623 @default.
- W3149829340 hasRelatedWork W2381539227 @default.
- W3149829340 hasRelatedWork W2392341793 @default.
- W3149829340 hasRelatedWork W2610030069 @default.
- W3149829340 hasRelatedWork W2788256329 @default.
- W3149829340 hasRelatedWork W2792903544 @default.
- W3149829340 hasRelatedWork W2900154505 @default.
- W3149829340 hasRelatedWork W3002421319 @default.
- W3149829340 hasRelatedWork W3030393388 @default.
- W3149829340 hasRelatedWork W3031787067 @default.
- W3149829340 hasRelatedWork W3032574059 @default.
- W3149829340 isParatext "false" @default.
- W3149829340 isRetracted "false" @default.
- W3149829340 magId "3149829340" @default.
- W3149829340 workType "article" @default.