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- W3149884186 abstract "BACKGROUNDRecent studies have reported that left ventricular dysfunction (ALVD) in humans is characterized by early neurohumoral activation. Specifically, atrial natriuretic factor (ANF) and norepinephrine are activated without activation of the renin-angiotensin-aldosterone system (RAAS). The current study describes hemodynamic and renal function associated with this neurohumoral profile in a canine model of early and presumably asymptomatic ventricular dysfunction. We hypothesized that the neurohumoral profile observed in ALVD is associated with preservation of renal function despite significant hemodynamic compromise.METHODS AND RESULTSALVD was produced by ventricular pacing at 180 beats per minute for 10 days. Intravascular volume expansion was performed before and after producing ALVD in eight conscious dogs. The model of ALVD was characterized by decreases in ejection fraction (48 +/- 2 to 29 +/- 4%), cardiac output (4.64 +/- 0.29 to 2.89 +/- 0.17 L/min), and mean arterial pressure (1..." @default.
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- W3149884186 date "1993-01-01" @default.
- W3149884186 modified "2023-09-24" @default.
- W3149884186 title "Cardiorenal and neurohumoral function in a canine model of early left ventricular dysfunction." @default.
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