FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3149885324> ?p ?o ?g. }

• W3149885324 endingPage "15" @default.
• W3149885324 startingPage "1" @default.
• W3149885324 abstract "Abstract Esculentoside A (EsA) is a kind of triterpenoid saponins from the root tuber of Phytolacca acinosa Roxb. It has extensive medicinal activity, such as antibacterial, anti‐inflammatory, immune regulation, and cell proliferation inhibition. However, some researches suggested that EsA can cause hepatotoxicity, whose mechanism is not precise. To ensure the safety and reliability in the clinical use of Phytolacca acinosa Roxb., it is necessary to establish a rapid and accurate method to evaluate the toxicity, analyze and verify the toxicity mechanism of EsA. Therefore, this research explored the mechanism of hepatotoxicity induced by EsA in rats and analyzed endogenous metabolites' changes in rat plasma by combining network toxicology with non‐targeted metabolomics. We obtained 58 critical targets of EsA induced hepatotoxicity in rats based on the strategy of network toxicology, including albumin, mitogen‐activated protein kinase 1, Caspase‐3, etc. Many important pathways were obtained by Kyoto Encyclopedia of Genes and Genomes enrichment analysis, such as HIF‐1 signaling pathway, TNF signaling pathway, IL‐17 signaling pathway, and other concerning pathways. Sixteen biomarkers, including 5‐hydroxykynurenamine, N ‐acetylserotonin, palmitic acid, etc., were screened from rat plasma using Ultra‐performance liquid chromatography coupled with quadrupole time of flight mass spectrometry (UPLC‐Q‐TOF/MS), mainly involve Glycerophospholipid metabolism, Tryptophan metabolism, and other metabolic pathways. Further analysis showed that EsA may induce liver injury by activating oxidative stress and energy metabolism disorders, triggering inflammation and apoptosis." @default.
• W3149885324 created "2021-04-13" @default.
• W3149885324 creator A5014993071 @default.
• W3149885324 creator A5016782315 @default.
• W3149885324 creator A5028807417 @default.
• W3149885324 creator A5029309754 @default.
• W3149885324 creator A5060434375 @default.
• W3149885324 creator A5065491621 @default.
• W3149885324 creator A5071048537 @default.
• W3149885324 creator A5071339229 @default.
• W3149885324 creator A5072564902 @default.
• W3149885324 creator A5086559201 @default.
• W3149885324 creator A5090859987 @default.
• W3149885324 date "2021-03-31" @default.
• W3149885324 modified "2023-09-26" @default.
• W3149885324 title "Integrating non‐targeted metabolomics and toxicology networks to study the mechanism of Esculentoside A‐induced hepatotoxicity in rats" @default.
• W3149885324 cites W1140817596 @default.
• W3149885324 cites W1503760388 @default.
• W3149885324 cites W1968186783 @default.
• W3149885324 cites W1972595076 @default.
• W3149885324 cites W1976622025 @default.
• W3149885324 cites W1977163370 @default.
• W3149885324 cites W1983937216 @default.
• W3149885324 cites W2016057875 @default.
• W3149885324 cites W2028619725 @default.
• W3149885324 cites W2032748118 @default.
• W3149885324 cites W2038132658 @default.
• W3149885324 cites W2038597144 @default.
• W3149885324 cites W2043950247 @default.
• W3149885324 cites W2054580598 @default.
• W3149885324 cites W2061233349 @default.
• W3149885324 cites W2079754865 @default.
• W3149885324 cites W2095431994 @default.
• W3149885324 cites W2156563694 @default.
• W3149885324 cites W2164993228 @default.
• W3149885324 cites W2170128720 @default.
• W3149885324 cites W2276174401 @default.
• W3149885324 cites W2408469245 @default.
• W3149885324 cites W2555560015 @default.
• W3149885324 cites W2566572220 @default.
• W3149885324 cites W2624683722 @default.
• W3149885324 cites W2702570342 @default.
• W3149885324 cites W2737794706 @default.
• W3149885324 cites W2748017674 @default.
• W3149885324 cites W2782835849 @default.
• W3149885324 cites W2787721428 @default.
• W3149885324 cites W2795279419 @default.
• W3149885324 cites W2801489819 @default.
• W3149885324 cites W2885538937 @default.
• W3149885324 cites W2899973702 @default.
• W3149885324 cites W2903228746 @default.
• W3149885324 cites W2909906311 @default.
• W3149885324 cites W2938891386 @default.
• W3149885324 cites W2967908602 @default.
• W3149885324 cites W2969456983 @default.
• W3149885324 cites W2980503164 @default.
• W3149885324 cites W3019913929 @default.
• W3149885324 doi "https://doi.org/10.1002/jbt.22761" @default.
• W3149885324 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33788351" @default.
• W3149885324 hasPublicationYear "2021" @default.
• W3149885324 type Work @default.
• W3149885324 sameAs 3149885324 @default.
• W3149885324 citedByCount "13" @default.
• W3149885324 countsByYear W31498853242021 @default.
• W3149885324 countsByYear W31498853242022 @default.
• W3149885324 countsByYear W31498853242023 @default.
• W3149885324 crossrefType "journal-article" @default.
• W3149885324 hasAuthorship W3149885324A5014993071 @default.
• W3149885324 hasAuthorship W3149885324A5016782315 @default.
• W3149885324 hasAuthorship W3149885324A5028807417 @default.
• W3149885324 hasAuthorship W3149885324A5029309754 @default.
• W3149885324 hasAuthorship W3149885324A5060434375 @default.
• W3149885324 hasAuthorship W3149885324A5065491621 @default.
• W3149885324 hasAuthorship W3149885324A5071048537 @default.
• W3149885324 hasAuthorship W3149885324A5071339229 @default.
• W3149885324 hasAuthorship W3149885324A5072564902 @default.
• W3149885324 hasAuthorship W3149885324A5086559201 @default.
• W3149885324 hasAuthorship W3149885324A5090859987 @default.
• W3149885324 hasConcept C104317684 @default.
• W3149885324 hasConcept C111472728 @default.
• W3149885324 hasConcept C138885662 @default.
• W3149885324 hasConcept C150194340 @default.
• W3149885324 hasConcept C152724338 @default.
• W3149885324 hasConcept C162317418 @default.
• W3149885324 hasConcept C185592680 @default.
• W3149885324 hasConcept C190283241 @default.
• W3149885324 hasConcept C192989942 @default.
• W3149885324 hasConcept C21565614 @default.
• W3149885324 hasConcept C2776055636 @default.
• W3149885324 hasConcept C2776151105 @default.
• W3149885324 hasConcept C31573885 @default.
• W3149885324 hasConcept C43617362 @default.
• W3149885324 hasConcept C55493867 @default.
• W3149885324 hasConcept C62231903 @default.
• W3149885324 hasConcept C62478195 @default.
• W3149885324 hasConcept C86803240 @default.
• W3149885324 hasConcept C89611455 @default.
• W3149885324 hasConcept C98274493 @default.

• next