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- W3149908830 abstract "Objective To study the role of intercellular adhesion molecule-1 (ICAM-1) and lymphocyte function-associated antigen-1 (LFA-1) in the pathogenesis of viral hepatitis B. Methods ICAM-1, LFA-1 and CD 8 expression in the livers of 11 healthy persons and 70 patients with HBV infection were studied by using immunohistochemical techniques. Hepatic coexpression of ICAM-1 and LFA-1 were studied using double staining immunohistochemical techniques. Results In the areas of inflammation and necrosis, intensive infiltration of LFA-1 positive lymphocytes were often observed around hepatocytes with enhanced ICAM-1 expression, with some of these lymphocytes in close contact with hepatocytes expressing ICAM-1. In addition, the debris of necrotic cells and injured heatocytes were found at the surrounding of LFA-1 positive lymphocytes. Conclusion The interaction of ICAM-1 and LFA-1 is involved in mediating the adhesion of lymphocytes and hepatocytes, and it plays an important part in the immunopathogenesis of chronic viral hepatitis B and severe viral hepatitis B." @default.
- W3149908830 created "2021-04-13" @default.
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- W3149908830 date "2000-01-01" @default.
- W3149908830 modified "2023-09-24" @default.
- W3149908830 title "The role of intercellular adhesion molecule-1/ lymphocyte function-associated antigen-1 in the pathogenesis of viral hepatitis B" @default.
- W3149908830 hasPublicationYear "2000" @default.
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