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- W3149910690 abstract "Hepatocellular 癌(HCC ) 在之中人的恶意最致命。在人的 multistep hepatocarcinogenesis 期间， genomic 获得在 proto-oncogenes 的激活代表重要机制。在许多情形，激活 oncogenes 为癌症治疗学作为预示的标记和目标两个都保持临床的含意。染色体 1q 拷贝的获得是在 HCC 的最经常检测的改变之一， 1q21 是最经常的最小的放大区域(3 月) 。更好的理解生理并且在 1q21 amplicon 以内的目标基因的 pathophysiological 角色将显著地在 HCC 致病改进我们的知识，并且可以导致忍受 1q21 的扩大的 HCC 的一个更有效的管理。如此的知识为 HCC 治疗为新治疗学的策略的发展有长期的含意。我们的研究组和其它，在 HCC 集中了于象 JTB， CKS1B，和 CHD1L 那样的 1q21 目标基因的鉴定和描述前进。在这评论，我们将在 1q21 amplicon 以内总结已知的目标基因的当前的科学知识， CHD1L 的精确 oncogenic 机制将详细被讨论。" @default.
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- W3149910690 date "2010-01-01" @default.
- W3149910690 modified "2023-09-24" @default.
- W3149910690 title "Chromosome 1q21 amplification and oncogenes in hepatocellular carcinoma" @default.
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