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• W3149922524 endingPage "153556" @default.
• W3149922524 startingPage "153556" @default.
• W3149922524 abstract "Background: During the last three decades systemic fungal infections associated to immunosuppressive therapies have become a serious healthcare problem. Clinical development of new antifungals is an urgent requirement. Since fungal but not mammalian cells are encased in a carbohydrate-containing cell wall, which is required for the growth and viability of fungi, the inhibition of cell wall synthesizing machinery, such as β(1,3)-D-glucan synthases (GS) and chitin synthases (CS) that catalyze the synthesis of β(1-3)-D-glucan and chitin, respectively, represent an ideal mode of action of antifungal agents. Although the echinocandins anidulafungin, caspofungin and micafungin are clinically well-established GS inhibitors for the treatment of invasive fungal infections, much effort must still be made to identify inhibitors of other enzymes and processes involved in the synthesis of the fungal cell wall. Purpose: Since natural products (NPs) have been the source of several antifungals in clinical use and also have provided important scaffolds for the development of semisynthetic analogues, this review was devoted to investigate the advances made to date in the discovery of NPs from plants that showed capacity of inhibiting cell wall synthesis targets. The chemical characterization, specific target, discovery process, along with the stage of development are provided here. Methods: An extensive systematic search for NPs against the cell wall was performed considering all the articles published until the end of 2020 through the following scientific databases: NCBI PubMed, Scopus and Google Scholar and using the combination of the terms “natural antifungals” and “plant extracts” with “fungal cell wall”. Results: The first part of this review introduces the state of the art of the structure and biosynthesis of the fungal cell wall and considers exclusively those naturally produced GS antifungals that have given rise to both existing semisynthetic approved drugs and those derivatives currently in clinical trials. According to their chemical structure, natural GS inhibitors can be classified as 1) cyclic lipopeptides, 2) glycolipids and 3) acidic terpenoids. We also included nikkomycins and polyoxins, NPs that inhibit the CS, which have traditionally been considered good candidates for antifungal drug development but have finally been discarded after enduring unsuccessful clinical trials. Finally, the review focuses in the most recent findings about the growing field of plant-derived molecules and extracts that exhibit activity against the fungal cell wall. Thus, this search yielded sixteen articles, nine of which deal with pure compounds and seven with plant extracts or fractions with proven activity against the fungal cell wall. Regarding the mechanism of action, seven (44%) produced GS inhibition while five (31%) inhibited CS. Some of them (56%) interfered with other components of the cell wall. Most of the analyzed articles refer to tests carried out in vitro and therefore are in early stages of development. Conclusion: This report delivers an overview about both existing natural antifungals targeting GS and CS activities and their mechanisms of action. It also presents recent discoveries on natural products that may be used as starting points for the development of potential selective and non-toxic antifungal drugs." @default.
• W3149922524 created "2021-04-13" @default.
• W3149922524 creator A5002331713 @default.
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• W3149922524 creator A5057945825 @default.
• W3149922524 creator A5076547080 @default.
• W3149922524 date "2021-07-01" @default.
• W3149922524 modified "2023-10-05" @default.
• W3149922524 title "Natural products targeting the synthesis of β(1,3)-D-glucan and chitin of the fungal cell wall. Existing drugs and recent findings" @default.
• W3149922524 cites W1484232481 @default.
• W3149922524 cites W1573671038 @default.
• W3149922524 cites W1601456657 @default.
• W3149922524 cites W1756263303 @default.
• W3149922524 cites W1875868434 @default.
• W3149922524 cites W1912191587 @default.
• W3149922524 cites W1915172560 @default.
• W3149922524 cites W1926119490 @default.
• W3149922524 cites W1928277783 @default.
• W3149922524 cites W1963648227 @default.
• W3149922524 cites W1965626289 @default.
• W3149922524 cites W1970825843 @default.
• W3149922524 cites W1971703129 @default.
• W3149922524 cites W1974541420 @default.
• W3149922524 cites W1974598566 @default.
• W3149922524 cites W1974672182 @default.
• W3149922524 cites W1976441391 @default.
• W3149922524 cites W1977676579 @default.
• W3149922524 cites W1978399068 @default.
• W3149922524 cites W1978888709 @default.
• W3149922524 cites W1980198334 @default.
• W3149922524 cites W1981052658 @default.
• W3149922524 cites W1981480550 @default.
• W3149922524 cites W1983613366 @default.
• W3149922524 cites W1984944078 @default.
• W3149922524 cites W1984998386 @default.
• W3149922524 cites W1987198359 @default.
• W3149922524 cites W1989425784 @default.
• W3149922524 cites W1995089151 @default.
• W3149922524 cites W1995173939 @default.
• W3149922524 cites W1997881540 @default.
• W3149922524 cites W1998892954 @default.
• W3149922524 cites W1999789022 @default.
• W3149922524 cites W2001001281 @default.
• W3149922524 cites W2001465291 @default.
• W3149922524 cites W2001679595 @default.
• W3149922524 cites W2004503571 @default.
• W3149922524 cites W2005047036 @default.
• W3149922524 cites W2006475796 @default.
• W3149922524 cites W2006787633 @default.
• W3149922524 cites W2008373245 @default.
• W3149922524 cites W2008480167 @default.
• W3149922524 cites W2009687830 @default.
• W3149922524 cites W2014391958 @default.
• W3149922524 cites W2015844835 @default.
• W3149922524 cites W2019332620 @default.
• W3149922524 cites W2021263559 @default.
• W3149922524 cites W2022715224 @default.
• W3149922524 cites W2024293274 @default.
• W3149922524 cites W2030609528 @default.
• W3149922524 cites W2031120074 @default.
• W3149922524 cites W2032338570 @default.
• W3149922524 cites W2033133245 @default.
• W3149922524 cites W2034571700 @default.
• W3149922524 cites W2034599708 @default.
• W3149922524 cites W2038204439 @default.
• W3149922524 cites W2038271699 @default.
• W3149922524 cites W2045960076 @default.
• W3149922524 cites W2046012592 @default.
• W3149922524 cites W2046045366 @default.
• W3149922524 cites W2048678419 @default.
• W3149922524 cites W2049302326 @default.
• W3149922524 cites W2049325376 @default.
• W3149922524 cites W2050355524 @default.
• W3149922524 cites W2062554833 @default.
• W3149922524 cites W2062759781 @default.
• W3149922524 cites W2064040958 @default.
• W3149922524 cites W2064059521 @default.
• W3149922524 cites W2065891345 @default.
• W3149922524 cites W2066621875 @default.
• W3149922524 cites W2067918379 @default.
• W3149922524 cites W2074338512 @default.
• W3149922524 cites W2074410024 @default.
• W3149922524 cites W2074993687 @default.
• W3149922524 cites W2075654276 @default.
• W3149922524 cites W2080167670 @default.
• W3149922524 cites W2080425942 @default.
• W3149922524 cites W2082389923 @default.
• W3149922524 cites W2085745929 @default.
• W3149922524 cites W2085784534 @default.
• W3149922524 cites W2086053834 @default.
• W3149922524 cites W2089054706 @default.
• W3149922524 cites W2093862878 @default.
• W3149922524 cites W2095657613 @default.
• W3149922524 cites W2096792374 @default.
• W3149922524 cites W2099312423 @default.
• W3149922524 cites W2099951777 @default.
• W3149922524 cites W2100073779 @default.

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