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- W3149930282 abstract "The effects of dl-(15 R)-15 methyl-PGE2 methyl ester(PG6E),in experimentalulcers induced by absolute alcohol,HCl,indomethacin,pyloric ligation and chronic acetic acid in ratswere studied.PG6E at doses 10～80μg·kg-1 was shown to have significant protective effect.PG6E(30～60μg· kg-1)was also found to reduce markedly the acid secretion, pepsin activity,DNAcontent of the juice collected from pylorus ligated stomach of rats and increase markedly the content ofgastric mucosa hexosamine in mice given PG6E(30～60μg·kg-1 po for 3 d).At dosesof 40～80μg· kg-1,PG6E was able to have no significant effect on gastric emptying time in rats andgastrointestinal tract movement in mice,It appears that PG6E was shown to inhibit the aggressivefactors and increase the protective factors of gastric mucosa,This may hopefully become a newantiulcer agent." @default.
- W3149930282 created "2021-04-13" @default.
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- W3149930282 date "1996-01-01" @default.
- W3149930282 modified "2023-09-26" @default.
- W3149930282 title "PROTECTION OF dl-(15R)-15 METHYL-PGE_2 METHYL ESTER(PG_6E)ON EXPERIMENTAL ULCERS IN RATS" @default.
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