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- W3149940571 abstract "Objective To observe the effects of the compatibility of Epimedium and Ligustrum lucidum (YN) on airway inflammation of asthmatic in rats with glucocorticoid (GC) intervention at different treatment stage (before withdrawal,during the withdrawal and after withdrawal).Methods Dexamethasone was injected into asthmatic model in rats with the oral gavage of YN.The index of airway inflammation was detected at the same time,including IFN-γ,TNF-α,IL-4,IL-5 comcentrations and EOS number branchoalveolar lavage fluids (BALF).Results Before the stage of withdrawing GC,group of YN and GC can reduce the number of EOS,the levels of IL-4,IL-5,and TNF-α,and increase the level of IFN-γ.During the GC withdrawal stage,group Ⅰ and Ⅱ of YN and GC can reduce the number of EOS and the level of IL-5,especially the effect of group Ⅰ of YN and GC to IL-5.Group Ⅰ of YN and GC can modulate IFN-γ/IL-4,and group Ⅱ of YN and GC can restrain TNF-α.After the GC stop stage,EOS number of model group with GC treatment is exacerbated.Group Ⅰ and Ⅱ of YN and GC can reduce the number of EOS.Group Ⅰ,Ⅱ and Ⅲ of YN and GC can reduce the level of IL-4,and increase IFN-γ.Group Ⅰ of YN and GC can regulate IFN-γ/IL-4 and the level of TNF-α significantly.And group Ⅱ of YN and GC restrains IL-5.Conclusions YN have different effects of anti inflammatory on asthmatic model of rats with the compatibility of GC.It can be infered that the compatibility of YN and GC has the tendency of synergy.Key words: Asthma; Airway inflammation; Glucocorticoid; Herba epimedium/Fructus ligustri lucidi" @default.
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- W3149940571 date "2012-10-20" @default.
- W3149940571 modified "2023-09-23" @default.
- W3149940571 title "Effects of herba epimedium and fructus ligustri iucidi on airway inflammation in rat asthma model with glucocorticoid intervention" @default.
- W3149940571 doi "https://doi.org/10.3760/cma.j.issn.1673-436x.2012.020.008" @default.
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