FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3149947355> ?p ?o ?g. }

• W3149947355 endingPage "5923" @default.
• W3149947355 startingPage "5917" @default.
• W3149947355 abstract "DNA self-assembly has created various nanostructured probes deployed in biosensors, whereas their direct charge contribution to sensitive bioassays remains elusive. Here, we report a supercharged tetrahedral DNA nanolabel-based electrochemical (eTDN) sensor for ultrasensitive detection of exosomal microRNAs (Exo-miRs). By using an “assembly before testing” strategy, there is high-efficiency recognition between the target Exo-miR and self-assembled TDN probe in a homogenous solution relative to surface-based hybridization. The TDN–miR complex can be further bridged specifically to form a stable sandwich construct with the surface-confined capture sequence via the base-stacking effect. The intrinsic supercharges of the TDN can adsorb numerous electroactive molecules in stoichiometry, which largely enhances the detection sensitivity, particularly by using electroneutral peptide nucleic acid instead of DNA probes to minimize the background signal. Using this approach, the eTDN sensor achieves a high sensitivity (34 aM), high specificity (against the single mismatch), and high selectivity (in serum). Furthermore, this ultrasensitive sensor provides a conjugation-free, non-enzymatic Exo-miR detection in blood and accurately distinguishes the breast cancer patients from normal individuals, showing to be a promising tool in the early diagnosis of malignant tumors." @default.
• W3149947355 created "2021-04-13" @default.
• W3149947355 creator A5017655089 @default.
• W3149947355 creator A5034942869 @default.
• W3149947355 creator A5036881486 @default.
• W3149947355 creator A5052544950 @default.
• W3149947355 creator A5058160530 @default.
• W3149947355 creator A5063481044 @default.
• W3149947355 creator A5078146505 @default.
• W3149947355 date "2021-04-02" @default.
• W3149947355 modified "2023-10-06" @default.
• W3149947355 title "Ultrasensitive Exosomal MicroRNA Detection with a Supercharged DNA Framework Nanolabel" @default.
• W3149947355 cites W1981777743 @default.
• W3149947355 cites W1982883071 @default.
• W3149947355 cites W1998748771 @default.
• W3149947355 cites W2001607419 @default.
• W3149947355 cites W2007542353 @default.
• W3149947355 cites W2017132242 @default.
• W3149947355 cites W2018302790 @default.
• W3149947355 cites W2019403558 @default.
• W3149947355 cites W2024949907 @default.
• W3149947355 cites W2040570597 @default.
• W3149947355 cites W2041857964 @default.
• W3149947355 cites W2049637011 @default.
• W3149947355 cites W2073341747 @default.
• W3149947355 cites W2077850544 @default.
• W3149947355 cites W2103931611 @default.
• W3149947355 cites W2127517948 @default.
• W3149947355 cites W2317449198 @default.
• W3149947355 cites W2328365473 @default.
• W3149947355 cites W2397101815 @default.
• W3149947355 cites W2430232674 @default.
• W3149947355 cites W2578061423 @default.
• W3149947355 cites W2743140482 @default.
• W3149947355 cites W2760464869 @default.
• W3149947355 cites W2763998334 @default.
• W3149947355 cites W2765454614 @default.
• W3149947355 cites W2802137188 @default.
• W3149947355 cites W2892981977 @default.
• W3149947355 cites W2897050640 @default.
• W3149947355 cites W2902554490 @default.
• W3149947355 cites W2904628185 @default.
• W3149947355 cites W2919199182 @default.
• W3149947355 cites W2931917782 @default.
• W3149947355 cites W2954661953 @default.
• W3149947355 cites W2973031927 @default.
• W3149947355 cites W3002111416 @default.
• W3149947355 cites W3012436130 @default.
• W3149947355 cites W3023007927 @default.
• W3149947355 cites W3032181161 @default.
• W3149947355 cites W3042916959 @default.
• W3149947355 cites W3045541969 @default.
• W3149947355 cites W3084787447 @default.
• W3149947355 cites W3092681411 @default.
• W3149947355 cites W3095369193 @default.
• W3149947355 doi "https://doi.org/10.1021/acs.analchem.1c00295" @default.
• W3149947355 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33798333" @default.
• W3149947355 hasPublicationYear "2021" @default.
• W3149947355 type Work @default.
• W3149947355 sameAs 3149947355 @default.
• W3149947355 citedByCount "38" @default.
• W3149947355 countsByYear W31499473552021 @default.
• W3149947355 countsByYear W31499473552022 @default.
• W3149947355 countsByYear W31499473552023 @default.
• W3149947355 crossrefType "journal-article" @default.
• W3149947355 hasAuthorship W3149947355A5017655089 @default.
• W3149947355 hasAuthorship W3149947355A5034942869 @default.
• W3149947355 hasAuthorship W3149947355A5036881486 @default.
• W3149947355 hasAuthorship W3149947355A5052544950 @default.
• W3149947355 hasAuthorship W3149947355A5058160530 @default.
• W3149947355 hasAuthorship W3149947355A5063481044 @default.
• W3149947355 hasAuthorship W3149947355A5078146505 @default.
• W3149947355 hasConcept C119203544 @default.
• W3149947355 hasConcept C12554922 @default.
• W3149947355 hasConcept C129312508 @default.
• W3149947355 hasConcept C130197536 @default.
• W3149947355 hasConcept C160756335 @default.
• W3149947355 hasConcept C171250308 @default.
• W3149947355 hasConcept C178790620 @default.
• W3149947355 hasConcept C185592680 @default.
• W3149947355 hasConcept C192562407 @default.
• W3149947355 hasConcept C21951064 @default.
• W3149947355 hasConcept C24107716 @default.
• W3149947355 hasConcept C2777343594 @default.
• W3149947355 hasConcept C33347731 @default.
• W3149947355 hasConcept C552990157 @default.
• W3149947355 hasConcept C55493867 @default.
• W3149947355 hasConcept C86803240 @default.
• W3149947355 hasConceptScore W3149947355C119203544 @default.
• W3149947355 hasConceptScore W3149947355C12554922 @default.
• W3149947355 hasConceptScore W3149947355C129312508 @default.
• W3149947355 hasConceptScore W3149947355C130197536 @default.
• W3149947355 hasConceptScore W3149947355C160756335 @default.
• W3149947355 hasConceptScore W3149947355C171250308 @default.
• W3149947355 hasConceptScore W3149947355C178790620 @default.
• W3149947355 hasConceptScore W3149947355C185592680 @default.
• W3149947355 hasConceptScore W3149947355C192562407 @default.
• W3149947355 hasConceptScore W3149947355C21951064 @default.

• next