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- W314994737 abstract "Magnesium (Mg 2+ ) is the second most abundant ion in the body but its regulation is poorly understood. Mg 2+ deficiency is known to interfere with the physiological regulation of other electrolytes, such as calcium (Ca 2+ ) and phosphate (Pi), and a number of hormones have been implicated in mediating such disturbances. Here we use a mouse model to understand how these changes occur over time. We show that in as little as one day, mice experienced a dramatic decrease in Mg 2+ and Ca 2+ excretion in urine. At the same time, Pi excretion was significantly increased. Given the speed of these changes, it is unlikely that FGF-23 regulates the increase in Pi excretion. Instead, other factors such as PTH may have a predominant role during the early stages of hypomagnesaemia. Our ultimate goal is to unravel the precise mechanism by which Mg 2+ deficiency affects the regulation of Ca 2+ and Pi, and understand the involvement of hormones such as PTH, FGF-23 and vitamin D in mediating these changes." @default.
- W314994737 created "2016-06-24" @default.
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- W314994737 date "2015-04-10" @default.
- W314994737 modified "2023-09-23" @default.
- W314994737 title "Development of Hypocalciuria and hyperphosphaturia during early stages of magnesium deprivation in mice" @default.
- W314994737 hasPublicationYear "2015" @default.
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