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- W3149947672 endingPage "382" @default.
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- W3149947672 abstract "Protein folding is a complex self-assembly process that enables a newly translated polypeptide to acquire the three-dimensional structure that defines its function. The mechanism of folding corresponds to the path on a funnel-shaped free energy landscape that the polypeptide traverses in order to reach the minimum that corresponds to a native tertiary structure or an ensemble of folded states. To understand protein folding means to characterize the folding transition state, intermediates, and thermodynamics and kinetics. Chemical protein synthesis is complementary to the available molecular biology and biophysical methods to study folding mechanisms. It enables precise modifications to polypeptide backbone and side chains, including single-atom substitutions, chiral editing, fine-tuning stereo-electronic interactions, artificial covalent linking, site-specific labeling with fluorophores, or incorporation of completely artificial building blocks. This chapter describes examples of the application of chemical approaches to the synthesis and modification of proteins in order to obtain unique insights into molecular determinants of protein folding." @default.
- W3149947672 created "2021-04-13" @default.
- W3149947672 creator A5089017359 @default.
- W3149947672 date "2021-02-16" @default.
- W3149947672 modified "2023-09-25" @default.
- W3149947672 title "Deciphering Protein Folding Using Chemical Protein Synthesis" @default.
- W3149947672 cites W1513488629 @default.
- W3149947672 cites W1553076485 @default.
- W3149947672 cites W173701656 @default.
- W3149947672 cites W1884193262 @default.
- W3149947672 cites W1963588863 @default.
- W3149947672 cites W1964387477 @default.
- W3149947672 cites W1969554101 @default.
- W3149947672 cites W1971108880 @default.
- W3149947672 cites W1975832531 @default.
- W3149947672 cites W1978033776 @default.
- W3149947672 cites W1979755931 @default.
- W3149947672 cites W1981775309 @default.
- W3149947672 cites W1982168813 @default.
- W3149947672 cites W1986326797 @default.
- W3149947672 cites W1986626670 @default.
- W3149947672 cites W1990373397 @default.
- W3149947672 cites W1993854766 @default.
- W3149947672 cites W1998948607 @default.
- W3149947672 cites W2000050283 @default.
- W3149947672 cites W2000203872 @default.
- W3149947672 cites W2000760799 @default.
- W3149947672 cites W2008440654 @default.
- W3149947672 cites W2013965057 @default.
- W3149947672 cites W2014985598 @default.
- W3149947672 cites W2021621012 @default.
- W3149947672 cites W2023662405 @default.
- W3149947672 cites W2027168767 @default.
- W3149947672 cites W2028130802 @default.
- W3149947672 cites W2029162393 @default.
- W3149947672 cites W2029871341 @default.
- W3149947672 cites W2030776726 @default.
- W3149947672 cites W2032121822 @default.
- W3149947672 cites W2033949460 @default.
- W3149947672 cites W2039601641 @default.
- W3149947672 cites W2040863157 @default.
- W3149947672 cites W2041459336 @default.
- W3149947672 cites W2042745266 @default.
- W3149947672 cites W2043883458 @default.
- W3149947672 cites W2044483297 @default.
- W3149947672 cites W2044730187 @default.
- W3149947672 cites W2047221000 @default.
- W3149947672 cites W2051145405 @default.
- W3149947672 cites W2054013705 @default.
- W3149947672 cites W2054573466 @default.
- W3149947672 cites W2056029668 @default.
- W3149947672 cites W2061638963 @default.
- W3149947672 cites W2062371417 @default.
- W3149947672 cites W2064901552 @default.
- W3149947672 cites W2068851741 @default.
- W3149947672 cites W2069658855 @default.
- W3149947672 cites W2070202134 @default.
- W3149947672 cites W2071825898 @default.
- W3149947672 cites W2073084525 @default.
- W3149947672 cites W2075460992 @default.
- W3149947672 cites W2078528113 @default.
- W3149947672 cites W2079011864 @default.
- W3149947672 cites W2079357620 @default.
- W3149947672 cites W2080130826 @default.
- W3149947672 cites W2083397106 @default.
- W3149947672 cites W2085031074 @default.
- W3149947672 cites W2085040401 @default.
- W3149947672 cites W2093064306 @default.
- W3149947672 cites W2096649736 @default.
- W3149947672 cites W2104518278 @default.
- W3149947672 cites W2105015586 @default.
- W3149947672 cites W2108107378 @default.
- W3149947672 cites W2116929905 @default.
- W3149947672 cites W2127836679 @default.
- W3149947672 cites W2141045359 @default.
- W3149947672 cites W2148777915 @default.
- W3149947672 cites W2156582479 @default.
- W3149947672 cites W2161162374 @default.
- W3149947672 cites W2164575327 @default.
- W3149947672 cites W2165186407 @default.
- W3149947672 cites W2165581033 @default.
- W3149947672 cites W2171371964 @default.
- W3149947672 cites W2171755502 @default.
- W3149947672 cites W2289547251 @default.
- W3149947672 cites W2326015692 @default.
- W3149947672 cites W2395256178 @default.
- W3149947672 cites W2486104684 @default.
- W3149947672 cites W2523568326 @default.
- W3149947672 cites W2534505019 @default.
- W3149947672 cites W2554336185 @default.
- W3149947672 cites W2560715646 @default.
- W3149947672 cites W2588181081 @default.
- W3149947672 cites W2588190188 @default.
- W3149947672 cites W2606900487 @default.
- W3149947672 cites W2623510814 @default.
- W3149947672 cites W2626618526 @default.
- W3149947672 cites W2727985092 @default.
- W3149947672 cites W2738383272 @default.