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- W3149955901 abstract "Histone 修正被建议为基因表示的 epigenetic 规定组成 histone 代码。然而，最近的研究证明 histones 不得不在抄写期间从染色质被拆卸。最近的证据不最后，建议 histones 可能在在抄写期间从染色质被移开以后是可能减解的。overexpressed 的降级而不是本国的 histones，过多的 histones 被显示了依赖于 proteasomes 和 ubiquitination。因为 26S proteasome 通常认出 polyubiquitinated 底层，表明 histones 的降级是否被 polyubiquitination 调停是批评的。出人意料地，有几乎不证实 ubiquitin ligase 能支持的那个任何东西组成的 histones 的 polyubiquitination 依赖的降级。同时， acetylation 和 phosphorylation 也与 histone 降级被联系。这评论试图由 posttranslational 蛋白质修正在 histones 和它的规定的联合抄写的降级上总结当前的知识。" @default.
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- W3149955901 date "2012-01-01" @default.
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- W3149955901 title "Transcription-Coupled Replacement of Histones： Degradation or Recycling？" @default.
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