Matches in SemOpenAlex for { <https://semopenalex.org/work/W3149958006> ?p ?o ?g. }
Showing items 1 to 69 of
69
with 100 items per page.
- W3149958006 abstract "Both the concept and the model of snug quantitative structure-activity relationship (QSAR) were pro-posed and developed for molecular design through constructing QSAR based on some known mode of receptor/ligand interactions. Many disadvantages of traditional models can be avoided by using the proposed method because the traditional models only determined upon molecular structural features in sample sets themselves. A genetic virtual screening of peptide/protein combinations (GVSPPC) is proposed for the first time by utilizing this idea to examine peptide/protein affinity activities. A genetic algorithm (GA) was developed for screening combinative targets with an interaction mode for virtual receptors. GVSPPC succeeds in disposing difficulties in rational QSAR,in order to search for the ligand/receptor interactions on conditions of unknown structures. Some bioactive oligo-/poly-peptide systems covering 58 angiotensin converting enzyme (ACE) inhibitors and 18 double site mutation residues in camel antibody protein cAb-Lys3 were investigated by GVSPPC with satisfactory results (R 2 cu0.91,Q 2 cv 0.86,ERMS=0.19-0.95),respectively,which demonstrates that GVSPPC is more inter-pretable in the ligand-receptor interaction than the traditional QSAR method." @default.
- W3149958006 created "2021-04-13" @default.
- W3149958006 creator A5042096631 @default.
- W3149958006 date "2008-01-01" @default.
- W3149958006 modified "2023-09-24" @default.
- W3149958006 title "Integration of genetic virtual screening patterns and latent multivariate modeling techniques for QSAR optimization based on combinations and/or interactions between peptides and proteins" @default.
- W3149958006 hasPublicationYear "2008" @default.
- W3149958006 type Work @default.
- W3149958006 sameAs 3149958006 @default.
- W3149958006 citedByCount "0" @default.
- W3149958006 crossrefType "journal-article" @default.
- W3149958006 hasAuthorship W3149958006A5042096631 @default.
- W3149958006 hasConcept C103697762 @default.
- W3149958006 hasConcept C116569031 @default.
- W3149958006 hasConcept C147597530 @default.
- W3149958006 hasConcept C164126121 @default.
- W3149958006 hasConcept C170493617 @default.
- W3149958006 hasConcept C185592680 @default.
- W3149958006 hasConcept C2779281246 @default.
- W3149958006 hasConcept C41008148 @default.
- W3149958006 hasConcept C53105671 @default.
- W3149958006 hasConcept C54355233 @default.
- W3149958006 hasConcept C55493867 @default.
- W3149958006 hasConcept C59593255 @default.
- W3149958006 hasConcept C70721500 @default.
- W3149958006 hasConcept C71240020 @default.
- W3149958006 hasConcept C86803240 @default.
- W3149958006 hasConceptScore W3149958006C103697762 @default.
- W3149958006 hasConceptScore W3149958006C116569031 @default.
- W3149958006 hasConceptScore W3149958006C147597530 @default.
- W3149958006 hasConceptScore W3149958006C164126121 @default.
- W3149958006 hasConceptScore W3149958006C170493617 @default.
- W3149958006 hasConceptScore W3149958006C185592680 @default.
- W3149958006 hasConceptScore W3149958006C2779281246 @default.
- W3149958006 hasConceptScore W3149958006C41008148 @default.
- W3149958006 hasConceptScore W3149958006C53105671 @default.
- W3149958006 hasConceptScore W3149958006C54355233 @default.
- W3149958006 hasConceptScore W3149958006C55493867 @default.
- W3149958006 hasConceptScore W3149958006C59593255 @default.
- W3149958006 hasConceptScore W3149958006C70721500 @default.
- W3149958006 hasConceptScore W3149958006C71240020 @default.
- W3149958006 hasConceptScore W3149958006C86803240 @default.
- W3149958006 hasLocation W31499580061 @default.
- W3149958006 hasOpenAccess W3149958006 @default.
- W3149958006 hasPrimaryLocation W31499580061 @default.
- W3149958006 hasRelatedWork W1559711086 @default.
- W3149958006 hasRelatedWork W1573275580 @default.
- W3149958006 hasRelatedWork W1997627388 @default.
- W3149958006 hasRelatedWork W2038076219 @default.
- W3149958006 hasRelatedWork W2039309547 @default.
- W3149958006 hasRelatedWork W2074360038 @default.
- W3149958006 hasRelatedWork W2084235643 @default.
- W3149958006 hasRelatedWork W2100720198 @default.
- W3149958006 hasRelatedWork W2119205090 @default.
- W3149958006 hasRelatedWork W2167456918 @default.
- W3149958006 hasRelatedWork W2212606255 @default.
- W3149958006 hasRelatedWork W2329064524 @default.
- W3149958006 hasRelatedWork W2516968687 @default.
- W3149958006 hasRelatedWork W2599911607 @default.
- W3149958006 hasRelatedWork W2738304688 @default.
- W3149958006 hasRelatedWork W2949477134 @default.
- W3149958006 hasRelatedWork W3011289639 @default.
- W3149958006 hasRelatedWork W3011356529 @default.
- W3149958006 hasRelatedWork W3211320963 @default.
- W3149958006 hasRelatedWork W973448257 @default.
- W3149958006 isParatext "false" @default.
- W3149958006 isRetracted "false" @default.
- W3149958006 magId "3149958006" @default.
- W3149958006 workType "article" @default.