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- W3149961029 abstract "To better understand the interaction between Schistosoma japonicum and its murine host,we characterized the immune response of CD4~+ T cells generated during an experimental S.japonicum infection based on different key aspects,from gene expression to cell behavior.Mouse oligonucleotide microarrays were used to compare gene expression profiles of CD4~+ T cells from spleens of mice at 0,3,6 and 13 weeks post-infection.Flow cytometry analysis was used to determine type 1 and type 2 cytokine-secreting CD4~+ T cells,to test apoptosis of CD4~+ T cells and to count CD4~+CD25~+ T cells,a kind of regulatory subpopulation of CD4~+ T cells.The percentage of interleukin-4-producing CD4~+ T cells was found to be much higher than that of γ-interferon-producing cells,especially after stimulation with S.japonicum egg antigen,which was consistent with type 1 and type 2 cytokine gene expression in the genechip.Microarray data also showed that S.japonicum induced the increased expression of Th2 response-related genes,whereas some transcripts related to the Th1 responsive pathway were depressed.Flow cytometry analysis showed a marked increase in the apoptotic CD4~+ T cells from 6 weeks post-infection and in the ratio of CD4~+CD25~+ to CD4~+ T cells in infected mice after 13 weeks.We therefore concluded that experimental infection of mice with S.japonicum resulted in a Th2-skewed immune response,which was to a great extent monitored by the immune regulatory network,including cytokine cross-modulation,cell apoptosis and the subpopulation of regulatory cells." @default.
- W3149961029 created "2021-04-13" @default.
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- W3149961029 date "2006-01-01" @default.
- W3149961029 modified "2023-09-23" @default.
- W3149961029 title "Characterization of CD4~+ T Cell Responses in Mice Infected with Schistosoma japonicum" @default.
- W3149961029 hasPublicationYear "2006" @default.
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