Matches in SemOpenAlex for { <https://semopenalex.org/work/W3149969307> ?p ?o ?g. }
- W3149969307 endingPage "75" @default.
- W3149969307 startingPage "64" @default.
- W3149969307 abstract "Abstract Fetal ovarian germ cells show characteristic energy metabolism status, such as enhanced mitochondrial metabolism as well as glycolysis, but their roles in early folliculogenesis are unclear. We show here that inhibition of pyruvate uptake to mitochondria by UK5099 in organ cultures of fetal mouse ovaries resulted in repressed early folliculogenesis without affecting energy production, survival of oocytes, or meiosis. In addition, the abnormal folliculogenesis by UK5099 was partially rescued by α-ketoglutarate and succinate, intermediate metabolites in the TCA cycle, suggesting the importance of those metabolites. The expression of TGFβ-related genes Gdf9 and Bmp15 in ovarian germ cells, which are crucial for folliculogenesis, was downregulated by UK5099, and the addition of recombinant GDF9 partially rescued the abnormal folliculogenesis induced by UK5099. We also found that early folliculogenesis was similarly repressed, as in the culture, in the ovaries of a germ cell-specific knockout of Mpc2, which encodes a mitochondria pyruvate carrier that is targeted by UK5099. These results suggest that insufficient Gdf9 expression induced by abnormal pyruvate metabolism in oocytes results in early follicular dysgenesis, which is a possible cause of defective folliculogenesis in humans." @default.
- W3149969307 created "2021-04-13" @default.
- W3149969307 creator A5002593526 @default.
- W3149969307 creator A5004955803 @default.
- W3149969307 creator A5015372152 @default.
- W3149969307 creator A5043350762 @default.
- W3149969307 creator A5048008812 @default.
- W3149969307 creator A5064409793 @default.
- W3149969307 creator A5072600163 @default.
- W3149969307 date "2021-04-06" @default.
- W3149969307 modified "2023-10-17" @default.
- W3149969307 title "Abnormal early folliculogenesis due to impeded pyruvate metabolism in mouse oocytes" @default.
- W3149969307 cites W1762789982 @default.
- W3149969307 cites W1932854961 @default.
- W3149969307 cites W1974690510 @default.
- W3149969307 cites W1976435237 @default.
- W3149969307 cites W1981252012 @default.
- W3149969307 cites W1995338702 @default.
- W3149969307 cites W1996171530 @default.
- W3149969307 cites W2013334588 @default.
- W3149969307 cites W2016535776 @default.
- W3149969307 cites W2027029928 @default.
- W3149969307 cites W2035010201 @default.
- W3149969307 cites W2037791269 @default.
- W3149969307 cites W2044203359 @default.
- W3149969307 cites W2044611683 @default.
- W3149969307 cites W2050395183 @default.
- W3149969307 cites W2051268087 @default.
- W3149969307 cites W2054655480 @default.
- W3149969307 cites W2055994125 @default.
- W3149969307 cites W2057733021 @default.
- W3149969307 cites W2058940068 @default.
- W3149969307 cites W2065899041 @default.
- W3149969307 cites W2081036392 @default.
- W3149969307 cites W2083248417 @default.
- W3149969307 cites W2084241850 @default.
- W3149969307 cites W2087130018 @default.
- W3149969307 cites W2089111937 @default.
- W3149969307 cites W2089645303 @default.
- W3149969307 cites W2110274446 @default.
- W3149969307 cites W2124682623 @default.
- W3149969307 cites W2130871836 @default.
- W3149969307 cites W2134294998 @default.
- W3149969307 cites W2150921965 @default.
- W3149969307 cites W2158217645 @default.
- W3149969307 cites W2160819114 @default.
- W3149969307 cites W2162301625 @default.
- W3149969307 cites W2162905148 @default.
- W3149969307 cites W2165233863 @default.
- W3149969307 cites W2170277678 @default.
- W3149969307 cites W2210628912 @default.
- W3149969307 cites W2216458814 @default.
- W3149969307 cites W2588557803 @default.
- W3149969307 cites W2734967358 @default.
- W3149969307 cites W2742586166 @default.
- W3149969307 cites W2784328279 @default.
- W3149969307 cites W2883828762 @default.
- W3149969307 cites W2982216374 @default.
- W3149969307 cites W3038463768 @default.
- W3149969307 cites W3093403567 @default.
- W3149969307 doi "https://doi.org/10.1093/biolre/ioab064" @default.
- W3149969307 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33824958" @default.
- W3149969307 hasPublicationYear "2021" @default.
- W3149969307 type Work @default.
- W3149969307 sameAs 3149969307 @default.
- W3149969307 citedByCount "4" @default.
- W3149969307 countsByYear W31499693072022 @default.
- W3149969307 countsByYear W31499693072023 @default.
- W3149969307 crossrefType "journal-article" @default.
- W3149969307 hasAuthorship W3149969307A5002593526 @default.
- W3149969307 hasAuthorship W3149969307A5004955803 @default.
- W3149969307 hasAuthorship W3149969307A5015372152 @default.
- W3149969307 hasAuthorship W3149969307A5043350762 @default.
- W3149969307 hasAuthorship W3149969307A5048008812 @default.
- W3149969307 hasAuthorship W3149969307A5064409793 @default.
- W3149969307 hasAuthorship W3149969307A5072600163 @default.
- W3149969307 hasBestOaLocation W31499693071 @default.
- W3149969307 hasConcept C126322002 @default.
- W3149969307 hasConcept C134018914 @default.
- W3149969307 hasConcept C163949779 @default.
- W3149969307 hasConcept C196843134 @default.
- W3149969307 hasConcept C2776690073 @default.
- W3149969307 hasConcept C2778324911 @default.
- W3149969307 hasConcept C2780536345 @default.
- W3149969307 hasConcept C5512455 @default.
- W3149969307 hasConcept C71924100 @default.
- W3149969307 hasConcept C86803240 @default.
- W3149969307 hasConcept C87073359 @default.
- W3149969307 hasConcept C95444343 @default.
- W3149969307 hasConceptScore W3149969307C126322002 @default.
- W3149969307 hasConceptScore W3149969307C134018914 @default.
- W3149969307 hasConceptScore W3149969307C163949779 @default.
- W3149969307 hasConceptScore W3149969307C196843134 @default.
- W3149969307 hasConceptScore W3149969307C2776690073 @default.
- W3149969307 hasConceptScore W3149969307C2778324911 @default.
- W3149969307 hasConceptScore W3149969307C2780536345 @default.
- W3149969307 hasConceptScore W3149969307C5512455 @default.
- W3149969307 hasConceptScore W3149969307C71924100 @default.