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- W3149986960 abstract "Downloaded from SPIE Digital Library on 05 Mar 2010 to Abstract. Cardiac architecture is inherently threedimensional, yet most characterizations rely on twodimensional histological slices or dissociated cells, which remove the native geometry of the heart. We previously developed a method for labeling intact heart sections without dissociation and imaging large volumes while preserving their three-dimensional structure. We further refine this method to permit quantitative analysis of imaged sections. After data acquisition, these sections are assembled using image-processing tools, and qualitative and quantitative information is extracted. By examining the reconstructed cardiac blocks, one can observe end-toend adjacent cardiac myocytes cardiac strands changing cross-sectional geometries, merging and separating from other strands. Quantitatively, representative crosssectional areas typically used for determining hypertrophy omit the three-dimensional component; we show that taking orientation into account can significantly alter the analysis. Using fast-Fourier transform analysis, we analyze the gross organization of cardiac strands in three dimensions. By characterizing cardiac structure in three dimensions, we are able to determine that the crystallin mutation leads to hypertrophy with cross-sectional area increases, but not necessarily via changes in fiber orientation distribution. © 2009 Society of Photo-Optical Instrumentation Engineers. DOI: 10.1117/1.3200939" @default.
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- W3149986960 date "2009-01-01" @default.
- W3149986960 modified "2023-09-27" @default.
- W3149986960 title "hree-dimensional cardiac architecture determined by wo-photon microtomy" @default.
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