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• W3150018154 abstract "Abstract Background: Drug delivery is a science that requires the development of tailored systems that can deliver defined quantities of a therapeutic payload at a specific target site, at a controlled release rate, with or without a specific trigger. However, several drug molecules cannot be formulated or administered by standard techniques as they exhibit poor water solubility or have limited stability in the human body. Polymeric multilayer capsules assembled using layer-by-layer technique (LbL) are promising candidates for complex tasks, such as storage, encapsulation, and release. These carriers can be readily engineered and functionalized with desired properties and are also flexible for specific changes with respect to mechanical stability, elasticity, morphology, biocompatibility, permeability, and surface characteristics. Multifunctionality and its ability to respond to various stimuli that can affect and control their properties are the most significant advantages of polyelectrolyte multilayered (PEM) capsules. Aim: The present study was aimed to develop a Fe-drug-loaded microbullets using a novel hybrid technology for magnetic targeted therapy and its comparative evaluation on rheumatoid arthritis. Methodology: Methotrexate magnetic microcapsules (MMC) and prednisolone magnetic microcapsules (PMC) were developed using the techniques detailed later. Poly(sodium 4-styrenesulfonate) (PSS)-doped porous CaCO3 core microparticles were prepared by biomimetic mineralization method and its surface morphology was observed and analyzed using SEM, followed by which particle size distribution, zeta potential, functional group characterization, thermal stability, porosity, and crystallinity were evaluated. Drug-loaded PSS-doped CaCO3 core microparticles were developed using solvent evaporation technique, and the resulting complex was assessed for drug loading and entrapment efficiency. Anionic poly(sodium 4-styrenesulfonate) and cationic poly(allylamine hydrochloride) in a suitable concentration were added alternatively up to 5 cycles to the drug incorporated PSS-doped CaCO3 microparticles by layer-by-layer procedure. Previously, iron oxide nanoparticles as ferrofluid prepared by coprecipitation technique were added in between the polyelectrolyte layers during the cycle. The CaCO3 core was preferentially removed to yielded drug-loaded magnetic microcapsules. The formulated MMC and PMC were evaluated for its morphology by SEM and TEM, particle size distribution, and zeta potential with zeta sizer, functional group characterization with FT-IR spectrometer, static magnetic properties with vibrating sample magnetometer, dynamic magnetic susceptibility with AC susceptometer, and stability studies. Adjuvant-induced arthritis rat model was used to evaluate the therapeutic efficacy of optimized MMC and PMC. Paw volume, hematological, biochemical parameters, radiological, and histopathological studies showed better therapeutic activity than standard drug. Results: Compared to the pure drugs, the developed MMC and PMC offer a promising drug carrier system with enhanced sustained drug release properties for effective treatment of rheumatoid arthritis. The obtained results discussed in concise justify that the developed methodology for magnetic drug targeting at rheumatoid arthritic joints would be more promising for further trials and clinical evaluation." @default.
• W3150018154 created "2021-04-13" @default.
• W3150018154 creator A5003692213 @default.
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• W3150018154 creator A5089798753 @default.
• W3150018154 date "2021-01-01" @default.
• W3150018154 modified "2023-10-14" @default.
• W3150018154 title "Polyelectrolyte multifaceted magnetic microcapsules for magnetic drug targeting at rheumatoid arthritic joints" @default.
• W3150018154 cites W1820155213 @default.
• W3150018154 cites W1963772454 @default.
• W3150018154 cites W1966612004 @default.
• W3150018154 cites W1967840767 @default.
• W3150018154 cites W1972002912 @default.
• W3150018154 cites W1973077250 @default.
• W3150018154 cites W1973232910 @default.
• W3150018154 cites W1978039187 @default.
• W3150018154 cites W1978962650 @default.
• W3150018154 cites W1981860292 @default.
• W3150018154 cites W1983565345 @default.
• W3150018154 cites W1983695731 @default.
• W3150018154 cites W1983747213 @default.
• W3150018154 cites W1985333575 @default.
• W3150018154 cites W1987844385 @default.
• W3150018154 cites W1989803924 @default.
• W3150018154 cites W1989993168 @default.
• W3150018154 cites W1990745645 @default.
• W3150018154 cites W1995828997 @default.
• W3150018154 cites W1998057611 @default.
• W3150018154 cites W1998910288 @default.
• W3150018154 cites W2001784553 @default.
• W3150018154 cites W2001833192 @default.
• W3150018154 cites W2004695587 @default.
• W3150018154 cites W2005892306 @default.
• W3150018154 cites W2006712306 @default.
• W3150018154 cites W2011590980 @default.
• W3150018154 cites W2012902568 @default.
• W3150018154 cites W2015883442 @default.
• W3150018154 cites W2018320089 @default.
• W3150018154 cites W2018965201 @default.
• W3150018154 cites W2022809525 @default.
• W3150018154 cites W2023505841 @default.
• W3150018154 cites W2023997482 @default.
• W3150018154 cites W2024384151 @default.
• W3150018154 cites W2025441457 @default.
• W3150018154 cites W2025966463 @default.
• W3150018154 cites W2027046873 @default.
• W3150018154 cites W2029255146 @default.
• W3150018154 cites W2029851331 @default.
• W3150018154 cites W2032773633 @default.
• W3150018154 cites W2032980963 @default.
• W3150018154 cites W2042122693 @default.
• W3150018154 cites W2042468204 @default.
• W3150018154 cites W2043673158 @default.
• W3150018154 cites W2044199954 @default.
• W3150018154 cites W2044607163 @default.
• W3150018154 cites W2047574319 @default.
• W3150018154 cites W2048676345 @default.
• W3150018154 cites W2049444048 @default.
• W3150018154 cites W2050475346 @default.
• W3150018154 cites W2051068497 @default.
• W3150018154 cites W2052605927 @default.
• W3150018154 cites W2056618936 @default.
• W3150018154 cites W2058783557 @default.
• W3150018154 cites W2059298390 @default.
• W3150018154 cites W2060308100 @default.
• W3150018154 cites W2061343957 @default.
• W3150018154 cites W2061663215 @default.
• W3150018154 cites W2064247637 @default.
• W3150018154 cites W2068359337 @default.
• W3150018154 cites W2070295374 @default.
• W3150018154 cites W2070324326 @default.
• W3150018154 cites W2071840467 @default.
• W3150018154 cites W2073431045 @default.
• W3150018154 cites W2074438676 @default.
• W3150018154 cites W2074459649 @default.
• W3150018154 cites W2075320504 @default.
• W3150018154 cites W2080338428 @default.
• W3150018154 cites W2081210808 @default.
• W3150018154 cites W2086350855 @default.
• W3150018154 cites W2089048912 @default.
• W3150018154 cites W2090706108 @default.
• W3150018154 cites W2090829032 @default.
• W3150018154 cites W2102760762 @default.
• W3150018154 cites W2103775523 @default.
• W3150018154 cites W2104669609 @default.
• W3150018154 cites W2108836062 @default.
• W3150018154 cites W2110826367 @default.
• W3150018154 cites W2116843833 @default.
• W3150018154 cites W2117208350 @default.
• W3150018154 cites W2119310864 @default.
• W3150018154 cites W2131872753 @default.
• W3150018154 cites W2133692536 @default.
• W3150018154 cites W2133915381 @default.
• W3150018154 cites W2136967594 @default.
• W3150018154 cites W2137208120 @default.

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