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• W3150019759 abstract "Abstract Dried blood spot (DBS) metabolite analysis is a central tool for the clinic, e.g. newborn screening. Instead of applying multiple analytical methods, a single liquid chromatography-mass spectrometry (LC-MS) method was developed for metabolites spanning from highly polar glucose to hydrophobic long-chain acylcarnitines. For liquid chromatography, a diphenyl column and a multi-linear solvent gradient operated at elevated flow rates allowed for an even-spread resolution of diverse metabolites. Injecting moderate volumes of DBS organic extracts directly, in contrast to evaporation and reconstitution, provided substantial increases in analyte recovery. Q Exactive MS settings were also tailored for sensitivity increases, and the method allowed for analyte retention time and peak area repeatabilities of 0.1-0.4 % and 2-10 %, respectively, for a wide polarity range of metabolites (logP −4.4 to 8.8). The method’s performance was suited for both untargeted analysis as well as targeted approaches, evaluated in clinically relevant experiments. Graphical Abstract" @default.
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• W3150019759 date "2021-03-26" @default.
• W3150019759 modified "2023-10-17" @default.
• W3150019759 title "Bridging the polar and hydrophobic metabolome in single-run untargeted liquid chromatography-mass spectrometry dried blood spot metabolomics for clinical purposes" @default.
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• W3150019759 doi "https://doi.org/10.1101/2021.03.22.21254119" @default.
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