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• W3150050403 abstract "Objective To explore the effect of Qiling Decoction( QD) combined highly active antiretroviral treatment( HAART) on expression levels of peripheral blood Th1 7 and Treg cells in HIV / AIDS patients. Methods Totally 5 5 HIV / AIDS patients were randomly assigned to the treatment group( 2 8 cases) and the combination group( 2 7 cases). Besides,2 1 HIV negative patients were recruited as the healthy control group. Those in the treatment group received HARRT alone,while those in the combination group received HAART combined QD. The observation lasted for 2 4 weeks. Meanwhile,according to peripheral blood CD4+T cell counts before treatment,HIV / AIDS patients were assigned to three subgroups. For patients in subgroup 1,1 cells / μL CD4+ T cell counts≤1 0 0 cells / μL; For patients in subgroup 2,1 0 1 cells / μL CD4+T cell counts≤2 0 0 cells / μL; For patients in subgroup 3,2 0 1 cells / μL CD4+T cell counts ≤ 3 5 0 cells / μL. Expression of peripheral blood Th1 7 and Treg cells,and number of CD4+T cell counts were detected using flow cytometry( FCM) in HIV / AIDS patients at the pre-treatment baseline,week 4,1 2,and 2 4,as well as those in the healthy control group. Results Compared with the healthy control group,CD4+T cell counts and the baseline expression level of Th1 7 cells in the peripheral blood of HIV / AIDS patients significantly decreased,the expression level of Tregcells significantly increased( P 0. 0 1). Compared with before treatment in the same group,CD4+T cell counts all increased at week 4,12,and 24 in the two treatment groups,showing statistical difference(P 0. 05,P 0. 01).There was no statistical difference in the effective rate at various CD4+T cell levels between the two groups(P 0. 05). There was no statistical difference in expression levels of Th17 and Treg cells between the combination group and the treatment group at any time point( allP 0. 05). The Th17 / Treg ration significantly increased in the combination group after 24 weeks of treatment,showing statistical difference when compared with the treatment group(U =2. 135,P =0. 038). Conclusion QD could improve the immune balance of Th17 / Treg cells,which might be one of its mechanisms for improving HIV / AIDS patients' immunity." @default.
• W3150050403 created "2021-04-13" @default.
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• W3150050403 date "2014-01-01" @default.
• W3150050403 modified "2023-09-26" @default.
• W3150050403 title "Effect of Qiling Decoction Combined HAART on Expression Levels of Treg Cells and Th17 in HIV/AIDS Patients" @default.
• W3150050403 hasPublicationYear "2014" @default.
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