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• W3150061411 abstract "Drug delivery devices are attractive alternatives to drugs usually orally administrated. Therefore, this work aimed to produce PLA/PBAT-based nanofibers for the controlled release of cilostazol, evaluating the effect of different drug concentrations (20 and 30%) over the properties of the fibers. The fibers were characterized by scanning electron microscopy (SEM), Fourier Transform Infrared Spectroscopy (FTIR), x-ray diffraction (XRD), differential scanning calorimetry (DSC), thermogravimetric (TG/DTG), and mechanical analysis. SEM results indicated a high concentration of drug crystals on the surface of the fibers that contained 20% of cilostazol. These fibers were also thinner, more crystalline, less thermally stable, and less fragile in comparison to the fibers containing 30% of cilostazol, according to the XRD, DSC, TG/DTG, and mechanical results. The controlled release assays indicated that the fibers containing 20% of cilostazol would be attractive for short-term releases, reaching the equilibrium after approximately 6 h, while the ones containing 30% would ensure a slower release (~ 12 h). Despite the differences, both fibers would improve and enhance the efficiency of the treatment, and they would also prevent possible side effects caused by the drug to the gastric system. • Ecovio®-based fibers were successfully produced by electrospinning. • The fibers have potential efficiency in short and long-term treatments. • The drug/matrix interaction decreased the crystallinity of the drug. • A solid-solution was formed between cilostazol and the Ecovio®-based fibers." @default.
• W3150061411 created "2021-04-13" @default.
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• W3150061411 date "2021-07-01" @default.
• W3150061411 modified "2023-10-03" @default.
• W3150061411 title "Electrospun poly(lactic acid) (PLA)/poly(butylene adipate-co-terephthalate) (PBAT) nanofibers for the controlled release of cilostazol" @default.
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• W3150061411 doi "https://doi.org/10.1016/j.ijbiomac.2021.03.174" @default.
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