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- W3150135488 abstract "Objective To study the clinical singificance and relationship between c-fms oncogene and hepatocellular carcinogensis, to further clarify the pathogenesis of hepatocellular carcinoma (HCC). Methods PCR- SSCP was performed, abnormal single strand band was cut off under ultraviolet, PCR was performed using the abnormal single band as template, PCR product was cloned into T vector to be sequenced. Histologi-cal classification was based on Edmondson standards Ⅰ-Ⅳ scale. Results The lengths of PCR products were consistent with the prediction with high specificity. SSCP showed two abnormal single strands in 18 HCC tissues of 301th codon PCR products. No abnormal single strands were observed in the 969th codon PCR products. DNA sequencing showed transition of Leu (TTG)→Ser (TCG) at 301st codon of CSF- 1R. Histological classification of the tumors were Edmondson Ⅲ in 11 case and Edmondson Ⅳ in 7 cases. The rumors had the characters of high degree malignancy and young age. Conclusion Mutation of c-fms codon at site 301 implied a molecular mechanism leading to hepatocellular carcinogenesis." @default.
- W3150135488 created "2021-04-13" @default.
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- W3150135488 date "2004-01-01" @default.
- W3150135488 modified "2023-09-27" @default.
- W3150135488 title "c-fins oncogene mutation in hepatocellular carcinoma and its clinical significance" @default.
- W3150135488 hasPublicationYear "2004" @default.
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