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- W315020913 abstract "Publisher Summary This chapter describes a study to investigate the effect of capsaicin on thermoregulation and thermosensitive neurons in the neonatal rat. Twenty-two new-born rats aged 6 h to 5 day were used. Under ether anesthesia, a stainless-steel guide cannula was subacutely implanted into the brain aimed more or less at the PO/AH. The animals were held in a prone position on a sponge rubber mat in a neutral environment where the animal could maintain the rectal temperature (Tre) at 36–37°C. Capsaicin, dissolved in Tween 80-ethanolsaline solution, was injected into PO/AH through an injection needle inserted into guide cannula in a dose of 5–10 μg in a fluid volume of 0.5–1.0 μl. In another series of experiments, capsaicin was given subcutaneously in non-operated neonatal rats in doses of 5–20 μg for the first injection and 10 μg−1 mg for the subsequent injections in a volume of 10–20 μl. It was observed that when capsaicin of 5–20 μg was subcutaneously injected in the neonatal rat, the Tre began to fall with latencies of 3–6 min and reached a lowest level 10–30 min after injection. Then, the Tre rose again to the preinjection level within 40–80 min." @default.
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- W315020913 date "1981-01-01" @default.
- W315020913 modified "2023-09-27" @default.
- W315020913 title "THE EFFECT OF CAPSAICIN ON THERMOREGULATION AND THERMOSENSITIVE NEURONS IN THE NEONATAL RAT" @default.
- W315020913 doi "https://doi.org/10.1016/b978-0-08-027354-9.50015-6" @default.
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