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- W3150242968 abstract "Tis sue adenosine triphosphatase (ATPase) activity [mumol Pi/(mg protein·h)], contents (mumol/g dry brain tissue)of Na~(+), K~(+), Ca~(2+) and histopathological changes in the CA-1 region of hippocampus were determined: After brain injury, there was a significant decrease of ATPase activity(Na~(+)-K~(+)-ATPase 0.425±0.066, Ca~(2+)-ATPase 0.419±0.020 vs Na~(+)-K~(+)-ATPase 0.635±0.043, Ca~(2+)-ATPase 0.527±0.017 in control group, P<0.01), and a remarkable increase of Na~(+), Ca~(2+) contents (Na~(+) 215.74±24.30, Ca~(2+) 4.59±0.25 vs Na~(+) 142.25±11.39, Ca~(2+) 3.73±0.38 in control group, P<0.01) in the hippocampus. In the salvia miltiorrhiza treated group, the inhibition of ATPase activity (Na~(+)-K~(+)-ATPase 0.593±0.027, Ca~(2+)-ATPase 0.468±0.040)and the increase of Na~(+), Ca~(2+)(Na~(+)181.72±19.62, Ca~(2+)4.08±0.38)in hippocampus(CA-1) were significantly lower than those in the untreated group(P<0.01). In addition, the neuronal damage observed under electron microscope was also ameliorated substantially." @default.
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- W3150242968 date "1994-01-01" @default.
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- W3150242968 title "Neuronal damage in the hippocampus (CA-1) after brain injury with and without Salvia miltiorrhiza treatment" @default.
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