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- W3150281007 abstract "HE study of Streptococcus pneumoniae has led to many insights into the pathogenesis of bacterial infections. The importance of the polysaccharide capsule of the organism in determining its virulence was indicated by studies of the protective role of anticapsular antibodies. 1-3 Of comparable importance was the observation that noncapsulated pneumococci caused progressive disease in rabbits with agranulocytosis, demonstrating thereby the pathogenic properties of the pneumococcal soma. 4 Investigation of the pathologic events in pneumococcal infection led to the discovery of DNA, 2,3 the development of the first bacterial polysaccharide vaccine, 5 and insights into the mechanism of action of penicillin, 6 antibiotic tolerance, 7 the complex structure of gram-positive cell walls, 8,9 and the inflammatory activities of grampositive bacterial cell walls. 10 Other gains were recognition of the benefit of controlling host responses during treatment of infectious diseases 11 and the development of genetic tools to study surface proteins in gram-positive bacteria. 12 In this review, we examine some of the molecular details of the pathogenesis of pneumococcal infection and relate them to the current understanding of the genesis of the clinical symptoms and signs associated with this type of infection." @default.
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- W3150281007 date "1995-01-01" @default.
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- W3150281007 title "PATHOGENESIS OF PNEUMOCOCCAL INFECTION" @default.
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