FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3150299583> ?p ?o ?g. }

• W3150299583 abstract "Myostatin (MSTN) is primarily expressed in muscle and plays an important role in muscle and fat development in pigs. However, there is little information about the regulation of pig MSTN. In order to elucidate whether pig MSTN could be regulated by muscle- and fat- related factors, the porcine MSTN promoter was amplified and cloned into pGL3-basic vector, and transfected into cells to analyze the transcriptional activity of promoter with muscle- and fat-related factors through Dual-lucifer- ase reporter assays. 5 0 -deletion expression showed that there was a negative-regulatory region located between nucleotides -1519 and -1236 bp, and there were some positive-regulatory regions located between -1236 and -568 bp. The longest fragment (1.7 kb) was cotransfected with muscle-related transcription factor myogenic differ- entiation 1 (MyoD), resulting in promoter transcriptional activity upregulation. The fragment was treated by the adipogenic agents (DIM) including dexamethasone, insu- lin, and isobutyl-1-methylxanthine (IBMX). We found that MSTN promoter transcriptional activity can be regulated by IBMX, but not by DIM. CCAAT/enhancer binding protein (C/EBP) a and C/EBPb, two proteins which are induced by DIM during adipogenesis were cotransfected with the 1.7-kb fragment, respectively, resulting in promoter tran- scriptional activity downregulation. Treating the fragment with rosiglitazone which induce the expression of peroxi- some proliferator-activated receptor c (PPARc), resulting in promoter transcriptional activity upregulation. Cotrans- fection experiments confirmed this result. Taken together, we showed that porcine MSTN could be upregulated by IBMX, MyoD, and PPARc but downregulated by C/EBPa and C/EBPb." @default.
• W3150299583 created "2021-04-13" @default.
• W3150299583 creator A5009811878 @default.
• W3150299583 creator A5034710860 @default.
• W3150299583 creator A5043816402 @default.
• W3150299583 creator A5059623301 @default.
• W3150299583 creator A5069735564 @default.
• W3150299583 date "2012-01-01" @default.
• W3150299583 modified "2023-10-14" @default.
• W3150299583 title "Functional analysis of pig myostatin gene promoter with some adipogenesis- and myogenesis-related factors" @default.
• W3150299583 cites W1968493176 @default.
• W3150299583 cites W1970930429 @default.
• W3150299583 cites W1984497160 @default.
• W3150299583 cites W1989862249 @default.
• W3150299583 cites W2019011732 @default.
• W3150299583 cites W2028966038 @default.
• W3150299583 cites W2033201924 @default.
• W3150299583 cites W2070418164 @default.
• W3150299583 cites W2071879210 @default.
• W3150299583 cites W2076720164 @default.
• W3150299583 cites W2077085828 @default.
• W3150299583 cites W2085917809 @default.
• W3150299583 cites W2096207972 @default.
• W3150299583 cites W2108815877 @default.
• W3150299583 cites W2110452261 @default.
• W3150299583 cites W2113040400 @default.
• W3150299583 cites W2128379002 @default.
• W3150299583 cites W2130122556 @default.
• W3150299583 cites W2137814808 @default.
• W3150299583 cites W2145274091 @default.
• W3150299583 cites W2153289066 @default.
• W3150299583 cites W2159674010 @default.
• W3150299583 cites W2165868509 @default.
• W3150299583 cites W2170831952 @default.
• W3150299583 hasPublicationYear "2012" @default.
• W3150299583 type Work @default.
• W3150299583 sameAs 3150299583 @default.
• W3150299583 citedByCount "0" @default.
• W3150299583 crossrefType "journal-article" @default.
• W3150299583 hasAuthorship W3150299583A5009811878 @default.
• W3150299583 hasAuthorship W3150299583A5034710860 @default.
• W3150299583 hasAuthorship W3150299583A5043816402 @default.
• W3150299583 hasAuthorship W3150299583A5059623301 @default.
• W3150299583 hasAuthorship W3150299583A5069735564 @default.
• W3150299583 hasConcept C101762097 @default.
• W3150299583 hasConcept C104317684 @default.
• W3150299583 hasConcept C122927707 @default.
• W3150299583 hasConcept C127561419 @default.
• W3150299583 hasConcept C150194340 @default.
• W3150299583 hasConcept C153911025 @default.
• W3150299583 hasConcept C170493617 @default.
• W3150299583 hasConcept C27153228 @default.
• W3150299583 hasConcept C2777488582 @default.
• W3150299583 hasConcept C2778106681 @default.
• W3150299583 hasConcept C2779276759 @default.
• W3150299583 hasConcept C2781298581 @default.
• W3150299583 hasConcept C3763915 @default.
• W3150299583 hasConcept C54355233 @default.
• W3150299583 hasConcept C86339819 @default.
• W3150299583 hasConcept C86803240 @default.
• W3150299583 hasConceptScore W3150299583C101762097 @default.
• W3150299583 hasConceptScore W3150299583C104317684 @default.
• W3150299583 hasConceptScore W3150299583C122927707 @default.
• W3150299583 hasConceptScore W3150299583C127561419 @default.
• W3150299583 hasConceptScore W3150299583C150194340 @default.
• W3150299583 hasConceptScore W3150299583C153911025 @default.
• W3150299583 hasConceptScore W3150299583C170493617 @default.
• W3150299583 hasConceptScore W3150299583C27153228 @default.
• W3150299583 hasConceptScore W3150299583C2777488582 @default.
• W3150299583 hasConceptScore W3150299583C2778106681 @default.
• W3150299583 hasConceptScore W3150299583C2779276759 @default.
• W3150299583 hasConceptScore W3150299583C2781298581 @default.
• W3150299583 hasConceptScore W3150299583C3763915 @default.
• W3150299583 hasConceptScore W3150299583C54355233 @default.
• W3150299583 hasConceptScore W3150299583C86339819 @default.
• W3150299583 hasConceptScore W3150299583C86803240 @default.
• W3150299583 hasLocation W31502995831 @default.
• W3150299583 hasOpenAccess W3150299583 @default.
• W3150299583 hasPrimaryLocation W31502995831 @default.
• W3150299583 hasRelatedWork W1916439338 @default.
• W3150299583 hasRelatedWork W1966609614 @default.
• W3150299583 hasRelatedWork W2001935171 @default.
• W3150299583 hasRelatedWork W2002083717 @default.
• W3150299583 hasRelatedWork W2031198305 @default.
• W3150299583 hasRelatedWork W2043673064 @default.
• W3150299583 hasRelatedWork W2055712821 @default.
• W3150299583 hasRelatedWork W2060084840 @default.
• W3150299583 hasRelatedWork W2094684347 @default.
• W3150299583 hasRelatedWork W2101785570 @default.
• W3150299583 hasRelatedWork W2109933477 @default.
• W3150299583 hasRelatedWork W2113069096 @default.
• W3150299583 hasRelatedWork W2137737168 @default.
• W3150299583 hasRelatedWork W2155627075 @default.
• W3150299583 hasRelatedWork W2382436036 @default.
• W3150299583 hasRelatedWork W2403101510 @default.
• W3150299583 hasRelatedWork W2419200684 @default.
• W3150299583 hasRelatedWork W251002125 @default.
• W3150299583 hasRelatedWork W2890418385 @default.
• W3150299583 hasRelatedWork W2748386027 @default.
• W3150299583 isParatext "false" @default.

• next