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- W3150337130 abstract "Objectives: Abdominal aortic aneurysm (AAA) is a chronic disease characterized by persistent inflammation maintained by an array of inflammatory cells and mediators. Interleukin 1 beta (IL-1β) has largely been considered a pro-inflammatory cytokine but, interestingly, our previous studies of human AAAs showed that activated T-cells from patients with AAAs expressed lower levels of IL-1β compared to matched control patients without AAAs. This led us to hypothesize that IL-1β could have a protective role in preventing the development of AAA. Methods: Abdominal aortic aneurysms were induced in IL-1 receptor KO (IL-1R-/-) and control mice using the CaCl2 murine model of AAA. Mice were sacrificed six weeks after aneurysm induction. Aortic diameters were measured and compared at the time of aneurysm induction and sacrifice. Aortic samples were further evaluated histologically using connective tissue staining to assess the aortic structure in both groups. Results: At the time of sacrifice, IL-1R-/- mice demonstr..." @default.
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- W3150337130 date "2015-05-01" @default.
- W3150337130 modified "2023-09-28" @default.
- W3150337130 title "Abstract 306: A Protective Role of IL-1 beta in Abdominal Aortic Aneurysms" @default.
- W3150337130 hasPublicationYear "2015" @default.
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