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- W3150353697 abstract "Objective Study the inhibitory effects of selenium on the production of basic lipid peroxidation and the secretion of extracellular matrix(ECM) of hepatocytes and ito cells in vitro.Methods Rat hepatocytes and ito cells were isolated and cultured.Results The results showed that selenium could obviously lower the production of malondialdehyde(MDA) and raise the activity of glutathione peroxidase(GSH Px) and inhibit the secretion of precollagen type Ⅲ (PCⅢ) in hepatocytes and ito cells as well as inhibit the secretion of hyaluronic acid in ito cells,and that there was a negative correlation between the level of PCⅢ and the ratio of GSH Px/MDA in both cells and a negative correlation between the levels of hyaluronic acid and the ratio of GSH Px/MDA in ito cells.Conclusions These studies indicated that selenium could lower the production of lipid peroxidation and inhibit the secretion of ECMs by raising the activity of GSH Px of rat hepatocytes and ito cells. [" @default.
- W3150353697 created "2021-04-13" @default.
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- W3150353697 date "2000-01-01" @default.
- W3150353697 modified "2023-09-25" @default.
- W3150353697 title "Effects of selenium on production of basic lipid peroxidation and excretion of extracellular matrix in rat cultured hepatocytes and Ito cells" @default.
- W3150353697 hasPublicationYear "2000" @default.
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