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• W3150356562 abstract "The present study aimed to compare the value of D-dimer measured on the 3rd day of hospitalization with admission D-dimer level in predicting in-hospital mortality in coronavirus disease 2019 (COVID-19) cases.In total, 231 patients with COVID-19 disease were included in the study. D-dimer levels were estimated using immunoturbidimetric assay with normal range of 0-500 μg/mL. In the current research, the primary outcome was the in-hospital mortality.In the present research, 39 (16.8%) COVID-19 cases died during the index hospitalization. In a multivariable analysis; age, D-dimer (3rd day) (OR: 1.00, 95% CI: 1.00-1.00, p<0.001), WBC count, and creatinine were independent predictors of the in-hospital death for COVID-19 cases. The ideal value of D-dimer level on the 3rd day of hospitalization was 774 μq/mL (area under curve (AUC): 0.903, 95% CI: 0.836-0.968; p<0.01) with sensitivity of 83.2% and specificity of 83.6%. It was noted that D-dimer level on the 3rd day of hospitalization had a higher sensitivity (83.2% vs 67.6%, respectively) and AUC value than that of D-dimer level on admission (0.903 vs 0.799, respectively).The main finding in this investigation was that D-dimer elevation on the 3rd of hospitalization is more sensitive predictor of in-hospital mortality than D-dimer elevation on admission in COVID-19 patients. Even though further investigations are needed to forecast precise prognosis in patients with COVID-19 disease in terms of D-dimer levels, we believe that D-dimer levels on the 3rd day of hospitalization have an enhanced potential to be used as a prognostic marker in routine clinical practice.Bu çalışma, koronavirüs hastalığı 2019 (COVID-19) hastalarında hastane içi mortaliteyi öngörmede 3. gün hastanede ölçülen D-dimer değeri ile başvuru D-dimer düzeyini karşılaştırmayı amaçlamaktadır.Toplamda, COVID-19’lu 231 hasta çalışmaya dâhil edildi. D-dimer seviyeleri, 0-500 μq/mL normal aralığı ile immünoturbidimetrik test kullanılarak ölçüldü. Mevcut araştırmada, birincil sonlanım hastane içi tüm nedenlere bağlı mortaliteydi.Mevcut araştırmada, 39 (%16,8) COVID-19 vakası hastanede yatarken öldü. Çok değişkenli analizde; yaş, D-dimer (3.üncü gün) (OR: 1.00, %95 CI: 1.00-1.00, p<0.001), beyaz küre sayısı ve kreatinin, COVID-19 vakaları için hastane içi ölümün bağımsız prediktörleri idi. Hastaneye yatışın 3’üncü gününde bakılan D-dimer seviyesi %83,2 duyarlılık ve %83,6 özgüllük ile ideal değeri 774 μq/mL’di (eğri altındaki alan (AUC): 0.903,%95 GA: 0,836-0.968; p<0.01). Hastaneye yatışın 3’üncü günündeki D-dimer düzeyinin, başvurdaki D-dimer düzeyinden daha yüksek duyarlılığa (sırasıyla %83,2’ye karşı %67,6) ve AUC değerine (sırasıyla 0,903’e karşı 0,799) sahip olduğu saptandı.Bu araştırmadaki temel bulgu, COVID-19 hastalarında hastaneye yatışının 3’üncü günündeki D-dimer yükselmesinin, hastaneye başvuru sırasındaki D-dimer seviyesine göre hastane içi mortalitenin daha duyarlı bir prediktörü olmasıdır. COVID-19 hastalığı olan hastalarda D-dimer düzeyi açısından kesin prognozu tahmin etmek için daha fazla araştırmaya ihtiyaç duyulsa da, 3. gün yatıştaki D-dimer düzeyinin rutinde prognostik bir belirteç olarak kullanılma potansiyeline sahip olduğunu düşünmekteyiz." @default.
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• W3150356562 date "2021-01-01" @default.
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• W3150356562 title "Comparison of D-dimer Level Measured on Third Day of Hospitalization with Admission D-dimer Level in Predicting In-hospital Mortality in COVID-19 Patients" @default.
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• W3150356562 doi "https://doi.org/10.5222/mmj.2021.07348" @default.
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