FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3150363062> ?p ?o ?g. }

• W3150363062 abstract "The exponential phase of aerobic growth is associated with risk of endogenous oxidative stress in which cells need to cope with an ;10-fold increase in the rate of H2O2generation. We addressed this issue by studying the regulationoftheintracellularconcentrationofH2O2inaerobicallygrowingEscherichiacoli.IntracellularH2O2 waskeptatanalmostconstantsteady-statevalueof ;0.2 mM(variation,lessthantwofold)overabroadrange of cell densities in rich medium. This regulation was achieved in part by a transient increase in the OxyRdependent transcription of the catalase gene katG (monitored by using a katG::lacZ operon fusion) during exponential growth, directly correlated with the increased rate of H2O2generation. The OxyR-regulated alkyl hydroperoxide reductase encoded byahpFCdid not detectably affect H2O2or catalase activity levels. Induction ofkatG,ahpFC,andperhapsothergenespreventedtheaccumulationofoxidativelymodifiedlipidsbutmaynot have protected DNA: the spontaneous mutation rate was significantly increased in both wild-type and DoxyR strains during exponential growth compared to that in these strains during lag or stationary phases. Strains lackingoxyRshowed throughout growth an 8- to 10-fold-higher frequency of spontaneous mutation than was seen for wild-type bacteria. TheahpD5allele also had a mutator effect half of that of DoxyRin exponential and stationary phases and equal to that of DoxyRin lag phase, perhaps by affecting organic peroxide levels. These results show that oxyR-regulated catalase expression is not solely an emergency response of E. coli to environmental oxidative stress, but also that it mediates a homeostatic regulation of the H2O2produced by normal aerobic metabolism. The activation of the oxyR regulon in this process occurs at much lower levels of H2O2 (;10 27 M) than those reported foroxyRactivation by exogenous H2O2(;10 25 M)." @default.
• W3150363062 created "2021-04-13" @default.
• W3150363062 creator A5054782752 @default.
• W3150363062 date "1997-01-01" @default.
• W3150363062 modified "2023-09-26" @default.
• W3150363062 title "Homeostatic Regulation of Intracellular Hydrogen Peroxide Concentration in Aerobically GrowingEscherichia coli" @default.
• W3150363062 cites W1483721839 @default.
• W3150363062 cites W1493439063 @default.
• W3150363062 cites W1537686192 @default.
• W3150363062 cites W1538849969 @default.
• W3150363062 cites W1546783991 @default.
• W3150363062 cites W1584652923 @default.
• W3150363062 cites W1595824689 @default.
• W3150363062 cites W1690379440 @default.
• W3150363062 cites W1749531655 @default.
• W3150363062 cites W1775749144 @default.
• W3150363062 cites W1832258074 @default.
• W3150363062 cites W1997762997 @default.
• W3150363062 cites W2001931771 @default.
• W3150363062 cites W2004079184 @default.
• W3150363062 cites W2022312170 @default.
• W3150363062 cites W2028622989 @default.
• W3150363062 cites W2029130174 @default.
• W3150363062 cites W2035604200 @default.
• W3150363062 cites W2044489468 @default.
• W3150363062 cites W2056613668 @default.
• W3150363062 cites W2064000861 @default.
• W3150363062 cites W2070213944 @default.
• W3150363062 cites W2094812249 @default.
• W3150363062 cites W2095088178 @default.
• W3150363062 cites W2095399465 @default.
• W3150363062 cites W2097960522 @default.
• W3150363062 cites W2128586413 @default.
• W3150363062 cites W2132826785 @default.
• W3150363062 cites W2172209113 @default.
• W3150363062 cites W2329855654 @default.
• W3150363062 cites W610665682 @default.
• W3150363062 cites W2090920017 @default.
• W3150363062 hasPublicationYear "1997" @default.
• W3150363062 type Work @default.
• W3150363062 sameAs 3150363062 @default.
• W3150363062 citedByCount "0" @default.
• W3150363062 crossrefType "journal-article" @default.
• W3150363062 hasAuthorship W3150363062A5054782752 @default.
• W3150363062 hasConcept C104317684 @default.
• W3150363062 hasConcept C134306372 @default.
• W3150363062 hasConcept C138885662 @default.
• W3150363062 hasConcept C143065580 @default.
• W3150363062 hasConcept C16613235 @default.
• W3150363062 hasConcept C179926584 @default.
• W3150363062 hasConcept C185592680 @default.
• W3150363062 hasConcept C203075996 @default.
• W3150363062 hasConcept C2776151105 @default.
• W3150363062 hasConcept C2778979269 @default.
• W3150363062 hasConcept C33923547 @default.
• W3150363062 hasConcept C41895202 @default.
• W3150363062 hasConcept C533411734 @default.
• W3150363062 hasConcept C55493867 @default.
• W3150363062 hasConcept C62361671 @default.
• W3150363062 hasConcept C75235859 @default.
• W3150363062 hasConcept C86803240 @default.
• W3150363062 hasConceptScore W3150363062C104317684 @default.
• W3150363062 hasConceptScore W3150363062C134306372 @default.
• W3150363062 hasConceptScore W3150363062C138885662 @default.
• W3150363062 hasConceptScore W3150363062C143065580 @default.
• W3150363062 hasConceptScore W3150363062C16613235 @default.
• W3150363062 hasConceptScore W3150363062C179926584 @default.
• W3150363062 hasConceptScore W3150363062C185592680 @default.
• W3150363062 hasConceptScore W3150363062C203075996 @default.
• W3150363062 hasConceptScore W3150363062C2776151105 @default.
• W3150363062 hasConceptScore W3150363062C2778979269 @default.
• W3150363062 hasConceptScore W3150363062C33923547 @default.
• W3150363062 hasConceptScore W3150363062C41895202 @default.
• W3150363062 hasConceptScore W3150363062C533411734 @default.
• W3150363062 hasConceptScore W3150363062C55493867 @default.
• W3150363062 hasConceptScore W3150363062C62361671 @default.
• W3150363062 hasConceptScore W3150363062C75235859 @default.
• W3150363062 hasConceptScore W3150363062C86803240 @default.
• W3150363062 hasLocation W31503630621 @default.
• W3150363062 hasOpenAccess W3150363062 @default.
• W3150363062 hasPrimaryLocation W31503630621 @default.
• W3150363062 hasRelatedWork W1491877983 @default.
• W3150363062 hasRelatedWork W179386124 @default.
• W3150363062 hasRelatedWork W1845564569 @default.
• W3150363062 hasRelatedWork W1878196482 @default.
• W3150363062 hasRelatedWork W1967676653 @default.
• W3150363062 hasRelatedWork W1968608652 @default.
• W3150363062 hasRelatedWork W1973735723 @default.
• W3150363062 hasRelatedWork W2020465347 @default.
• W3150363062 hasRelatedWork W2094005308 @default.
• W3150363062 hasRelatedWork W2094540492 @default.
• W3150363062 hasRelatedWork W2115942087 @default.
• W3150363062 hasRelatedWork W2148685325 @default.
• W3150363062 hasRelatedWork W2351994173 @default.
• W3150363062 hasRelatedWork W2368476937 @default.
• W3150363062 hasRelatedWork W2401358004 @default.
• W3150363062 hasRelatedWork W2416340431 @default.
• W3150363062 hasRelatedWork W2467538608 @default.
• W3150363062 hasRelatedWork W2886664121 @default.
• W3150363062 hasRelatedWork W289345403 @default.

• next