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- W3150386864 endingPage "472" @default.
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- W3150386864 abstract "Introduction: Steroid sulfatase (STS) enzyme is responsible for transforming the inactive sulfate metabolites of steroid sex hormones into the active free steroids. Both the deficiency and the over-expression of STS are associated with the pathophysiology of certain diseases. This article provides the readership with a comprehensive review about STS enzyme and its recently reported inhibitors.Areas covered: In the present article, we reviewed the structure, location, and substrates of STS enzyme, physiological functions of STS, and disease states related to over-expression or deficiency of STS enzyme. STS inhibitors reported during the last five years (2016-present) have been reviewed as well.Expert opinion: Irosustat is the most successful STS inhibitor drug candidate so far. It is currently under investigation in clinical trials for treatment of estrogen-dependent breast cancer. Non-steroidal sulfamate is the most favorable scaffold for STS inhibitor design. They can be beneficial for the treatment of hormone-dependent cancers and neurodegenerative disorders without significant estrogenic side effects. Moreover, dual-acting molecules (inhibitors of STS + another synergistic mechanism) can be therapeutically efficient." @default.
- W3150386864 created "2021-04-13" @default.
- W3150386864 creator A5008771790 @default.
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- W3150386864 creator A5049219975 @default.
- W3150386864 creator A5091070851 @default.
- W3150386864 date "2021-04-19" @default.
- W3150386864 modified "2023-10-16" @default.
- W3150386864 title "Steroid sulfatase inhibitors: the current landscape" @default.
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