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- W3150406695 abstract "The MTT assay showed that the mutant-type endostatin had a lower dose IC_(50) (27 #mu#g/ml) than the wild-type one (IC_(50)=185 #mu#g/ml) and the anti-tumor activity of the former was 6 times than that of the latter. Cellular migration assay showed that tumor cell migration was inhibited by both mutant-type and wild-type endostatin, with the inhibition rate 89.94% and 68.95%, respectively. The results suggest that in addition to inhibiting angiogenesis, endostatin can also inhibit proliferation and migration of tumor cell. The anti-tumor activity of mutant-type endostatin is raised with its RGDRGD sequence binding with integrin." @default.
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- W3150406695 date "2005-01-01" @default.
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- W3150406695 title "Structural modification and anti--tumor activity change of recombinant human endostatin" @default.
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