Matches in SemOpenAlex for { <https://semopenalex.org/work/W3150411941> ?p ?o ?g. }
- W3150411941 endingPage "237" @default.
- W3150411941 startingPage "226" @default.
- W3150411941 abstract "Alpha-synuclein (α-syn) which encoded by SNCA plays a critical role in the neurotransmission, vesicle dynamics, and neuroplasticity. Alteration to SNCA expression is associated with major depressive disorder. However, the pathogenic mechanism of SNCA in depression remains unknown. Herein, we reported that SNCA was up-regulated in the peripheral blood of major depressive disorder (MDD) patients and the depressive mice. Chronic restraint stress (CRS) also up-regulated the SNCA expression in the hippocampus. Moreover, over-expression of SNCA in the hippocampus triggered spontaneous depressive-like behaviors under the non-stressed conditions in mice, and knockout of SNCA could reverse CRS-induced depressive-like behaviors. SNCA led to synapse loss and neuronal cell death in the hippocampus possibly via complement-mediated microglial engulfment and inflammation, and thus contributed to the pathogenesis of depressive disorder. Overall, hippocampal SNCA and complement system are involved in the pathogenesis of depressive disorder and it provides a new perspective for the occurrence of depressive disorder." @default.
- W3150411941 created "2021-04-13" @default.
- W3150411941 creator A5002574185 @default.
- W3150411941 creator A5014747513 @default.
- W3150411941 creator A5021226128 @default.
- W3150411941 creator A5039392522 @default.
- W3150411941 creator A5054488942 @default.
- W3150411941 creator A5086136998 @default.
- W3150411941 date "2021-07-01" @default.
- W3150411941 modified "2023-10-12" @default.
- W3150411941 title "Hippocampal alpha-synuclein mediates depressive-like behaviors" @default.
- W3150411941 cites W1583501533 @default.
- W3150411941 cites W1697553032 @default.
- W3150411941 cites W1904023784 @default.
- W3150411941 cites W1932752244 @default.
- W3150411941 cites W1967029543 @default.
- W3150411941 cites W1979591162 @default.
- W3150411941 cites W1990473626 @default.
- W3150411941 cites W1996940510 @default.
- W3150411941 cites W2000235613 @default.
- W3150411941 cites W2007340454 @default.
- W3150411941 cites W2008386957 @default.
- W3150411941 cites W2009573330 @default.
- W3150411941 cites W2022755347 @default.
- W3150411941 cites W2039465503 @default.
- W3150411941 cites W2043835731 @default.
- W3150411941 cites W2044428616 @default.
- W3150411941 cites W2054931962 @default.
- W3150411941 cites W2056419918 @default.
- W3150411941 cites W2058487562 @default.
- W3150411941 cites W2060035717 @default.
- W3150411941 cites W2061794524 @default.
- W3150411941 cites W2066943555 @default.
- W3150411941 cites W2092935640 @default.
- W3150411941 cites W2096327192 @default.
- W3150411941 cites W2097241494 @default.
- W3150411941 cites W2103506573 @default.
- W3150411941 cites W2110413824 @default.
- W3150411941 cites W2131207606 @default.
- W3150411941 cites W2136429865 @default.
- W3150411941 cites W2149559973 @default.
- W3150411941 cites W2151498098 @default.
- W3150411941 cites W2255138985 @default.
- W3150411941 cites W2314634699 @default.
- W3150411941 cites W2341088037 @default.
- W3150411941 cites W2416643466 @default.
- W3150411941 cites W2587082207 @default.
- W3150411941 cites W2618794795 @default.
- W3150411941 cites W2625499130 @default.
- W3150411941 cites W2668364657 @default.
- W3150411941 cites W2740570637 @default.
- W3150411941 cites W2777441928 @default.
- W3150411941 cites W2788337440 @default.
- W3150411941 cites W2789312859 @default.
- W3150411941 cites W2800099178 @default.
- W3150411941 cites W2800847995 @default.
- W3150411941 cites W2806131738 @default.
- W3150411941 cites W2904156057 @default.
- W3150411941 cites W2941009031 @default.
- W3150411941 cites W2947126461 @default.
- W3150411941 cites W2948074239 @default.
- W3150411941 cites W2986782615 @default.
- W3150411941 cites W3009322768 @default.
- W3150411941 cites W3013820019 @default.
- W3150411941 cites W3036454441 @default.
- W3150411941 cites W3090676790 @default.
- W3150411941 doi "https://doi.org/10.1016/j.bbi.2021.03.020" @default.
- W3150411941 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33775831" @default.
- W3150411941 hasPublicationYear "2021" @default.
- W3150411941 type Work @default.
- W3150411941 sameAs 3150411941 @default.
- W3150411941 citedByCount "7" @default.
- W3150411941 countsByYear W31504119412022 @default.
- W3150411941 countsByYear W31504119412023 @default.
- W3150411941 crossrefType "journal-article" @default.
- W3150411941 hasAuthorship W3150411941A5002574185 @default.
- W3150411941 hasAuthorship W3150411941A5014747513 @default.
- W3150411941 hasAuthorship W3150411941A5021226128 @default.
- W3150411941 hasAuthorship W3150411941A5039392522 @default.
- W3150411941 hasAuthorship W3150411941A5054488942 @default.
- W3150411941 hasAuthorship W3150411941A5086136998 @default.
- W3150411941 hasConcept C126322002 @default.
- W3150411941 hasConcept C127445978 @default.
- W3150411941 hasConcept C148762608 @default.
- W3150411941 hasConcept C15744967 @default.
- W3150411941 hasConcept C169760540 @default.
- W3150411941 hasConcept C2778941446 @default.
- W3150411941 hasConcept C2779134260 @default.
- W3150411941 hasConcept C2779144063 @default.
- W3150411941 hasConcept C2779734285 @default.
- W3150411941 hasConcept C2780051608 @default.
- W3150411941 hasConcept C2780942790 @default.
- W3150411941 hasConcept C2781161787 @default.
- W3150411941 hasConcept C2781449126 @default.
- W3150411941 hasConcept C513476851 @default.
- W3150411941 hasConcept C71924100 @default.
- W3150411941 hasConceptScore W3150411941C126322002 @default.
- W3150411941 hasConceptScore W3150411941C127445978 @default.