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- W3150508958 abstract "瞄准：为了在肝损伤上评估大蒜的 hepatoprotective 效果，由异菸肼(ZNH ) 和 rifampicin (RIF ) 导致了。方法：称 150-200 g 的 Wistar 老鼠为 28 d 与 INH 和 RIF 每日的各个的 50 mg/kg 口头上地被对待。为 hepatoprotective 研究， 0.25 g/kg 口头上地每刚准备的大蒜匀浆的天被管理在 INH+RIF 剂量前的半个小时。浆液丙氨酸 aminotransferase (中高音) ， aspartate aminotransferase (著名计算机生产厂商) 和胆红素在 d 上被估计 0， 14， 21，和 28 在所有老鼠。组织学的分析被执行估计损害到肝。每氧化(LPO ) ，作为氧化应力和非蛋白质的一个标记，为抗氧化剂的 thiols (谷胱甘肽) 铺平的类脂化合物在肝匀浆被测量。结果：有 INH+RIF 的老鼠的处理(50 mg/kg 每天每) 在由提高的浆液中高音，著名计算机生产厂商，和胆红素判定了的所有对待的动物的导致的 hepatotoxicity 铺平，焦点的 hepatocytic 坏死(6/8 ) 的存在和门 triaditis (8/8 ) 。同时每天在 0.25 g/kg 的剂量管理的大蒜在 INH+RIF 阻止了组织病理学说的损害的正式就职共同对待的动物除了在 4 个动物，它显示出仅仅中等的门 triaditis。组织学的变化在 INH+RIF 与氧化应力相关对待的动物。作为与 INH+RIF 相比与谷胱甘肽(P<0.05 ) 和 LPO (P<0.05 ) 的底层高级的显示出的 INH+RIF 一起每天大蒜匀浆收到了 0.25 g/kg 的组对待组。结论：刚准备的大蒜匀浆在实验动物模型免于导致 INH+RIF 的肝损伤。" @default.
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- W3150508958 date "2006-01-01" @default.
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- W3150508958 title "Effect of garlic on isoniazid and rifampicin-induced hepatic injury in rats" @default.
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