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- W3150531296 abstract "• Sphingosin-1-phosphate receptor 3 plays an important role in different cells. • The function of the S1PR3 signaling in different diseases remains controversial. • S1PR3 may be a disease biomarker and a potential therapeutic target. Sphingosine-1-phosphate (S1P) is a bioactive lipid which regulates a series of physiological and pathological processes via binding to five S1P receptors (S1PR1-5). Although S1PR1-3 are widely expressed, the study of S1PRs, however, mainly addressed S1PR1 and S1PR2, and few studies focus on S1PR3-5. In recent years, a growing number of studies have shown that S1PR3 plays an important role in cell proliferation, differentiation, apoptosis, and migration, but its function is still controversial. This is the first comprehensive review paper about the role of S1PR3 signaling in cardiovascular function, tissue fibrosis, cancer, immune response, and neurological function. In addition, existing S1PR3 agonists and antagonists are listed at the end of the article, and we also put forward our opinion on the dispute of S1PR3 function." @default.
- W3150531296 created "2021-04-13" @default.
- W3150531296 creator A5014185434 @default.
- W3150531296 creator A5014942240 @default.
- W3150531296 creator A5037938980 @default.
- W3150531296 creator A5066922569 @default.
- W3150531296 creator A5076857904 @default.
- W3150531296 date "2021-08-01" @default.
- W3150531296 modified "2023-09-25" @default.
- W3150531296 title "Sphingosine-1-phosphate receptor 3 signaling" @default.
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